Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

This week, I am joined by microbiologist Dr. Sarkis Mazmanian, the Luis B. and Nelly Soux Professor at Caltech, to discuss the microbiome's connection to human health—especially the gut-brain axis. Dr. Mazmanian discusses his research evolution from infectious diseases to the microbiome’s role in neurodevelopment and neurodegeneration, as well as how gut microbes influence neurological health, behavior, and conditions like Parkinson's, autism, and depression. He highlights the human gut microbe symbiosis, early-life microbial exposure's influence, and the adult microbiome's malleability. We explore microbiome-based therapeutics' potential, challenges in translating animal models to humans, personalized medicine's future, the microbiome's impact on drug efficacy, gut bacteria's influence on behaviors and cravings, and the importance of a healthy gut diet. Please enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: AG1: Get a FREE 1-year supply of Vitamin D3+K2 AND 5 free AG1 Travel Packs 👉drinkAG1.com/richroll InsideTracker: Use code RICHROLL at checkout and enjoy 10% OFF the InsideTracker Subscription and any plan 👉insidetracker.com/richroll On: 10% OFF your first order of high-performance shoes and apparel w/ code RICHROLL10👉on.com/richroll Roka: Unlock 20% OFF sunglasses & eyewear with code RICHROLL 👉roka.com/richroll Go Brewing: Use the code Rich Roll for 15% OFF my favorite non-alcoholic brews 👉gobrewing.com Squarespace: Use the offer code RichRoll to save 10% off your first purchase of a website or domain 👉Squarespace.com/RichRoll

Episoder(976)

Bruce Wagner Writes Transgressive Novels About Tragedy & Transcendence

Bruce Wagner Writes Transgressive Novels About Tragedy & Transcendence

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29 Jan 2h 2min

Decoding Women's Health: Dr. Elizabeth Poynor On Midlife Hormonal Changes, Interventions That Actually Work, & Why Medicine Left Women Behind

Decoding Women's Health: Dr. Elizabeth Poynor On Midlife Hormonal Changes, Interventions That Actually Work, & Why Medicine Left Women Behind

Dr. Elizabeth Poynor is a gynecologic oncologist, Chair of Women's Health at Atria Health Institute, and host of the podcast “Decoding Women's Health.” This conversation explores why women's health h...

26 Jan 1h 32min

Reclaim Your Excellence: The Path To A Meaningful & Joyous Life w/ Brad Stulberg

Reclaim Your Excellence: The Path To A Meaningful & Joyous Life w/ Brad Stulberg

Brad Stulberg is a bestselling author, executive coach, and one of my favorite thinkers on sustainable high performance. This conversation explores the dualities in personal development, discipline a...

19 Jan 2h 3min

Cognitive Scientist Maya Shankar On Navigating Unexpected Life Changes, The Neuroscience Of Identity, & How To Unlock Your Next Self

Cognitive Scientist Maya Shankar On Navigating Unexpected Life Changes, The Neuroscience Of Identity, & How To Unlock Your Next Self

Dr. Maya Shankar is a cognitive scientist, host of the podcast “A Slight Change of Plans,” and author of “The Other Side of Change.” This conversation explores the challenge of navigating involuntary...

15 Jan 2h 6min

Dr. Will Bulsiewicz: Heal Your Gut, Reduce Inflammation & Optimize Your Microbiome

Dr. Will Bulsiewicz: Heal Your Gut, Reduce Inflammation & Optimize Your Microbiome

Dr. Will Bulsiewicz is a gastroenterologist, one of the world's foremost authorities on the gut microbiome, and author of “Plant Powered Plus.” This conversation explores the gut-immune connection as...

12 Jan 2h 27min

Mark Manson On Vanity Goals, Self-Sabotage & How To Actually Change Your Life

Mark Manson On Vanity Goals, Self-Sabotage & How To Actually Change Your Life

Mark Manson is the author of The Subtle Art of Not Giving a F*ck and host of the Solved podcast. Back for his third appearance (eps. 476, 882), we skip the backstory and pull questions from a fishbow...

5 Jan 1h 48min

Best of 2025 (Part Two): The Year’s Most Enduring Insights

Best of 2025 (Part Two): The Year’s Most Enduring Insights

The finale is here. Let's close this thing out. Part 2 explores courage, honesty, creativity, relationships, and balance. Bravery. Addiction. Love. Mastery. And why fulfillment doesn't require sacrif...

29 Des 20251h 51min

Best of 2025 (Part One): Conversations That Shaped Us

Best of 2025 (Part One): Conversations That Shaped Us

Happy holidays from the RRP mothership. Another year in the rearview. Time for what's become one of my favorite traditions, our annual “Best Of.” 12 years running now. This year was packed with an a...

22 Des 20251h 46min

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