Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

This week, I am joined by microbiologist Dr. Sarkis Mazmanian, the Luis B. and Nelly Soux Professor at Caltech, to discuss the microbiome's connection to human health—especially the gut-brain axis. Dr. Mazmanian discusses his research evolution from infectious diseases to the microbiome’s role in neurodevelopment and neurodegeneration, as well as how gut microbes influence neurological health, behavior, and conditions like Parkinson's, autism, and depression. He highlights the human gut microbe symbiosis, early-life microbial exposure's influence, and the adult microbiome's malleability. We explore microbiome-based therapeutics' potential, challenges in translating animal models to humans, personalized medicine's future, the microbiome's impact on drug efficacy, gut bacteria's influence on behaviors and cravings, and the importance of a healthy gut diet. Please enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: AG1: Get a FREE 1-year supply of Vitamin D3+K2 AND 5 free AG1 Travel Packs 👉drinkAG1.com/richroll InsideTracker: Use code RICHROLL at checkout and enjoy 10% OFF the InsideTracker Subscription and any plan 👉insidetracker.com/richroll On: 10% OFF your first order of high-performance shoes and apparel w/ code RICHROLL10👉on.com/richroll Roka: Unlock 20% OFF sunglasses & eyewear with code RICHROLL 👉roka.com/richroll Go Brewing: Use the code Rich Roll for 15% OFF my favorite non-alcoholic brews 👉gobrewing.com Squarespace: Use the offer code RichRoll to save 10% off your first purchase of a website or domain 👉Squarespace.com/RichRoll

Episoder(976)

Earth's Hidden Wisdom: Paul Hawken On Reframing Carbon, Consciousness & Why Hope Lies Within Nature's Intelligence

Earth's Hidden Wisdom: Paul Hawken On Reframing Carbon, Consciousness & Why Hope Lies Within Nature's Intelligence

Paul Hawken is one of the great elder statesmen of environmentalism, a bestselling author, and the mind behind Drawdown and Regeneration.  This conversation explores the biosphere's intrinsic intelli...

8 Mai 20251h 38min

Kate Courtney Is Sending It: The Champion Mountain Biker On Redefining Elite Performance, Finding Joy In The Struggle & Seeing Sport As An Authentic Expression

Kate Courtney Is Sending It: The Champion Mountain Biker On Redefining Elite Performance, Finding Joy In The Struggle & Seeing Sport As An Authentic Expression

Kate Courtney is a world champion mountain biker, Olympian, and the palmarès-rich face of American cycling. This conversation examines Kate's Olympic torch moment with Tom Cruise, her athletic philos...

5 Mai 20252h 10min

Inside ‘The Telepathy Tapes’: Creator Ky Dickens Reveals The Extraordinary Story Behind The Podcast Sensation

Inside ‘The Telepathy Tapes’: Creator Ky Dickens Reveals The Extraordinary Story Behind The Podcast Sensation

Ky Dickens is the award-winning filmmaker behind "The Telepathy Tapes," the viral podcast phenomenon. This conversation explores the intersection of neurodiversity and consciousness as Ky shares her ...

28 Apr 20251h 56min

The Modern Elder: Chip Conley On Reframing Midlife, Cultivating True Wisdom & Finding Purpose In Life's Second Half

The Modern Elder: Chip Conley On Reframing Midlife, Cultivating True Wisdom & Finding Purpose In Life's Second Half

Chip Conley is a hospitality maverick, founder of Modern Elder Academy, and the entrepreneurial sage who helped transform Airbnb from a startup to a global phenomenon. This conversation explores midl...

24 Apr 20252h 1min

Beyond 10% Happier: Dan Harris On Meditation As A Superpower, Transforming Anxiety, & Finding Peace In Uncertain Times

Beyond 10% Happier: Dan Harris On Meditation As A Superpower, Transforming Anxiety, & Finding Peace In Uncertain Times

Dan Harris is the former ABC News anchor whose on-air panic attack catalyzed his transformation from skeptical journalist to meditation ambassador.   This conversation explores Dan’s journey with medi...

21 Apr 20251h 54min

Phil Stutz & Elise Loehnen Share Tools For Inner Well-being, How To Embrace Pain, Uncertainty & Constant Work As Divine Invitations, & Why Everything You’re Avoiding Will Transform Your Life

Phil Stutz & Elise Loehnen Share Tools For Inner Well-being, How To Embrace Pain, Uncertainty & Constant Work As Divine Invitations, & Why Everything You’re Avoiding Will Transform Your Life

Phil Stutz is the legendary psychiatrist, author, and protagonist in the Netflix documentary “Stutz.” Alongside co-author and writer Elise Loehnen, they explore their new book “True & False Magic.”   ...

14 Apr 20251h 29min

Power, Property, & Prestige: Kurt Sutter & Katey Sagal Share The Unfiltered Truth About Marriage, Recovery, Success Addiction & The Path Back To Purpose

Power, Property, & Prestige: Kurt Sutter & Katey Sagal Share The Unfiltered Truth About Marriage, Recovery, Success Addiction & The Path Back To Purpose

Kurt Sutter and Katey Sagal are the Hollywood power couple behind “Sons of Anarchy,” numerous iconic performances, and hosts of the podcast “PIE.”   This conversation strips bare the intoxicating trap...

10 Apr 20252h 3min

Let Them Theory: Mel Robbins On Reclaiming Your Power, Finding Freedom In Letting Go & The Simple Tool That's Transforming Millions of Lives

Let Them Theory: Mel Robbins On Reclaiming Your Power, Finding Freedom In Letting Go & The Simple Tool That's Transforming Millions of Lives

Mel Robbins is a celebrated podcast host, #1 New York Times bestselling author, and one of the most sought-after experts in mindset and behavior change.   This conversation explores the paradox at the...

7 Apr 20251h 50min

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