Special Episode: Dr. Sara Manning Peskin & A Molecule Away from Madness

Special Episode: Dr. Sara Manning Peskin & A Molecule Away from Madness

We live on the edge. Whether we fail to acknowledge it or try not to think of it, that fact remains true for most of us. A chemical shift, a rogue protein, a marauding molecule - our brains are vulnerable to an array of attacks that could dramatically alter our connection with the world and ourselves. In this episode of the TPWKY book club, Dr. Sara Manning Peskin, MD, MS, assistant professor of clinical neurology at the University of Pennsylvania and author, joins us to discuss her book A Molecule Away from Madness: Tales of the Hijacked Brain. Deeply fascinating, occasionally terrifying, and always empathetic, A Molecule Away from Madness features individual cases of the brain gone awry. Dr. Manning Peskin artfully combines these emotional and personal stories with approachable explanations of how our brains work and historical descriptions of how we gained this understanding. Tune in to this captivating conversation wherever you get your podcasts!

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Episoder(279)

Ep 205 Cancer Part 4: Where do things stand today?

Ep 205 Cancer Part 4: Where do things stand today?

For the entirety of our species’ history, our approach to cancer has largely been to react, to design new therapies and better combinations of treatments. This energy has certainly been well-spent, bu...

31 Mar 1h 19min

Ep 204 Cancer Part 3: How do we treat it?

Ep 204 Cancer Part 3: How do we treat it?

A century and a half ago, the list of effective cancer treatments was essentially a single entry: surgery. Today, in 2026, you’d need pages to contain the number of treatments available, and multiple ...

24 Mar 1h 32min

Special Episode: Lawrence Ingrassia & A Fatal Inheritance

Special Episode: Lawrence Ingrassia & A Fatal Inheritance

For centuries, physicians noticed that cancer sometimes ran in families, but until the 1960s, an answer to this mystery remained out of reach. Only then were scientists beginning to unlock the cellula...

17 Mar 45min

Ep 203 Cancer Part 2: Why does it happen?

Ep 203 Cancer Part 2: Why does it happen?

Each of our cells can become cancerous. It’s an uncomfortable, yet unavoidable truth. Nor is it a truth restricted to our species - cancer is a consequence of complex life. The features that make a ce...

10 Mar 1h 18min

Ep 202 Cancer Part 1: What is it?

Ep 202 Cancer Part 1: What is it?

Cancer has touched every one of us in some capacity, and learning of a diagnosis inspires many more questions than it answers. In this four-part series on cancer, we aim to lay a foundation of knowled...

3 Mar 1h 36min

Special Episode: Jon Adams and Edmund Ramsden & Rat City

Special Episode: Jon Adams and Edmund Ramsden & Rat City

What happens if you put a bunch of rats in an enclosure and provision them with unlimited food and water? Researcher John B. Calhoun was committed to finding out. Results from Calhoun’s “rat utopia” e...

24 Feb 56min

Ep 201 Poop Part 2: Flushed away

Ep 201 Poop Part 2: Flushed away

Poop is an incredibly valuable and massively underutilized resource. However, most of us don’t see it that way because of our evolutionarily ingrained disgust towards poop. Flush toilets and intricate...

17 Feb 1h 21min

Ep 200 Poop Part 1: How the sausage gets made

Ep 200 Poop Part 1: How the sausage gets made

It might be stinky and it might be unpleasant to behold, but we all do it. For many of us, our poop is out of sight, out of mind once we flush it away. But for the next hour and fifteen minutes or so,...

10 Feb 1h 11min

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