XXY HYPOGONADISM & METABOLISM

XXY HYPOGONADISM & METABOLISM

🔴 Part IV - “Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology.”

Episodes 5 to 11 are dedicated to the most extensive review of research on XXY to date, divided into 7 parts for ease of listening.

Episode 8 (Part IV) shows that many XXY males go through puberty without being detected, yet hypogonadism invariably presents significant problems sooner or later. Rarely diagnosed, it can be easily identified through routine palpation of the testes, and is one of the most straightforwards aspects of KS to treat with testosterone from puberty onwards.

XXY also results in 5 times higher risk Diebetes II, and almost 50% of individuals end up metabolical syndrome, However it seems to be a myth that testosterone treatment helps, as metabolic syndrome seems present from childhood on (truncal obesity in childhood is its biggest predictor). Other earlier age measures such as physical activity and limitation of sugar intake may be more effective.

Authors: Claus H. Gravholt, Simon Chang, Mikkel Wallentin, Jens Fedder, Philip Moore and Anne Skakkebæk.

Publication: Endocrine Reviews, 2018. doi: 10.1210/er.2017-00212. Original Article (pdf download) available on chromodiversity.com.

Keywords: #HypergonadotropicHypogonadism, #FSH #LH #Testes #BMI #InsulinResistence #MuscleBuildup #Glucose #MetabolicSyndrome #TruncalObesity #Diabetes #AutoimmuneDisease #Genomics #Diet #Exercise

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Episoder(40)

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