The Chromodiversity™ Podcast19 Jul 2022

XXY NEUROCOGNITION, QoL & SOCIOECONOMICS

🔴 Part VI - “Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology.”

Episodes 5 to 11 are dedicated to the most extensive review of research on XXY to date. Episode 10 (Part VI) shows XXY children and adults have 10x higher incidence of dyslexia, with reading & writing challenges in 75% of cases. Executive function can also be affected. Some of these issues may dissipate in adulthood, possibly due to acquisition of environmental learning skills.

Brain structure variations may explain such differences, not all necessary negative. For instance XXY males have increased blood oxygen brain levels when listening to sounds and using their hands, and normal adaptation to perceptual input.

75% find Quality of Life negatively impacted on all scales of the WHO’s QoL Assessment, with poor sleep a particularly strong predictor. The majority of are dissatisfied with health care services. The authors call for improved education of health care providers and emphasize the need for a holistic approach.

Authors: Claus H. Gravholt, Simon Chang, Mikkel Wallentin, Jens Fedder, Philip Moore and Anne Skakkebæk.

Publication: Endocrine Reviews, 2018. doi: 10.1210/er.2017-00212. Original Article (pdf download) available on chromodiversity.com.

Keywords: #Neurocognition #QoL #Socioeconomics #Intelligence #Language #ExecutiveFunction #BrainStructure #SkewedXchromosomeInactivation #BOLDsignal #FunctionalNeuroimagining #ExperientialLearning

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Episoder(40)

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