Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Episoder(1360)

How Gordon Ryan Saved Nicky Rod's Life

How Gordon Ryan Saved Nicky Rod's Life

⚕️ Use code "MPMD" for 10% off our in-depth blood test panels at Marek Health: https://marekhealth.com/mpmd 📌 Check out the full podcast here: https://youtu.be/bLyFvocD-eU?si=mqvX0-GOnUsAsVKR ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ TWITTER: https://twitter.com/Derek_Fitness SNAPCHAT: https://www.snapchat.com/add/derek-fit TIKTOK: https://www.tiktok.com/@moreplates FACEBOOK: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #craigjones #gordonryan #nickyrod ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

19 Aug 20245min

How Hard Is It To Get A Black Belt? 🥋

How Hard Is It To Get A Black Belt? 🥋

📌 Check out the full podcast here: https://youtu.be/6uy75kr_O5k ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ TWITTER: https://twitter.com/Derek_Fitness SNAPCHAT: https://www.snapchat.com/add/derek-fit TIKTOK: https://www.tiktok.com/@moreplates FACEBOOK: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #craigjones #cji #jiujitsu ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

19 Aug 20247min

Omega-3 Elixir 🐟 - Stop Buying Rancid Fish Oil

Omega-3 Elixir 🐟 - Stop Buying Rancid Fish Oil

🐟 Omega-3 Elixir™ Is Now Live! The Most Robust & Rigorously Vetted Omega-3 Support: https://gorillamind.com/products/omega-3-elixir | code "MPMD" for 10% off (and another 20% off on subscriptions) 📌 The Omega-3 Index Blood Test: https://marekdiagnostics.com/products/omega-check | code "MPMD" for 10% off ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ TWITTER: https://twitter.com/Derek_Fitness SNAPCHAT: https://www.snapchat.com/add/derek-fit TIKTOK: https://www.tiktok.com/@moreplates FACEBOOK: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #fishoil #omega3 #supplements ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

16 Aug 202416min

Becoming Elite, PEDs, BJJ, MMA, & The HIGH STAKES $3 Million CJI Tournament - Craig Jones

Becoming Elite, PEDs, BJJ, MMA, & The HIGH STAKES $3 Million CJI Tournament - Craig Jones

⚕️ Use code "MPMD" for 10% off our in-depth blood test panels at Marek Health: https://marekhealth.com/mpmd ———————————— 🕑 Time Stamps: 0:00:00 - Craigs Jones’ first time in Canada and the guy who threatened to kill him 0:02:00 - Who is Craig Jones? 0:02:57 - The $3 million CJI tournament anonymous donor, and bringing $1 million cash on Joe Rogan’s podcast 0:05:43 - Why Craig started Jiu-Jitsu. MMA was illegal in Australia 0:06:47 - Why Joe Rogan refuses to come to Canada. Would Derek ever leave Canada? 0:12:45 - Jiu-Jitsu vs MMA and the ROI for the risk of brain damage 0:13:23 - Beating drug testing in tested sports 0:14:29 - Who are the most elite Jiu-Jitsu athletes who could also do well in MMA? 0:16:56 - There was no money in Jiu-Jitsu when Craig started 0:18:01 - The misconception that Jiu-Jitsu isn’t gay and weird 0:19:38 - The top 3 martial arts you should learn to defend yourself 0:21:12 - The most important form of combat to learn first before anything else 0:21:59 - The most ineffective combat skill that is often mistakenly believed to be useful 0:24:29 - Bragging rights of winning tournaments 0:25:59 - How B-Team is playing 4D chess by claiming to be the second best 0:27:40 - Craig’s Instagram beefs, and who the weirdest athletes are 0:28:50 - Brazilian Jiu-Jitsu (BJJ) vs. Jiu-Jitsu 0:30:21 - The kids who came up to Derek on the beach asking about building muscle for Jiu-Jitsu 0:31:33 - How train to progress as quickly as possible in Jiu-Jitsu 0:32:41 - The curse of Larry Wheels, and athletes ruining their careers by training stupidly 0:35:52 - The performance downsides of getting juiced out of your mind massive for Jiu-Jitsu 0:37:24 - The Danaher Death Squad and why Craig, Nicky Ryan, Nicky Rod, and Ethan Crelinsten left 0:39:34 - How hard is it to get a black belt and how long does it take? Is it a covert multi-level marketing scheme? 0:47:28 - How to optimize week of training to max out progress in Jiu-Jitsu 0:49:28 - How to learn submissions as quickly as possible 0:51:39 - Craig's tier list for the best and worst submissions 0:55:45 - The craziest submission Craig has ever hit 0:56:44 - Jiu-Jitsu paywalled instructional videos from elite athletes 1:00:00 - Why most of the best Jiu-Jitsu athletes in the world make less than $100K per year 1:02:27 - The top prizes for winning the most elite submission grappling competition in the world (ADCC), and now the $2.6 million at stake for the first Craig Jones Invitational (CJI) 1:03:30 - The identity of the anonymous donor who put up $3 million for CJI 1:05:15 - Why Craig is so motivated to take down ADCC 1:07:18 - Sponsor: Marek Health 1:08:37 - The super fights, custom fight pit to push action, and why CJI will be the most elite, high stakes, grappling tournament on earth 1:18:28 - The origins of the Abu Dhabi Combat Club (ADCC) 1:19:27 - Craig’s blood work and his review of Marek Health so far 1:21:27 - The importance of expert oversight in Jiu-Jitsu to optimize health, performance, and longevity in the sport 1:25:48 - Do you need to be on PEDs to excel in Jiu-Jitsu? 1:29:15 - The world championship combination of autism and steroids in Jiu-Jitsu 1:30:51 - Life changing money at CJI. Winning $1 million at CJI vs. ADCC prestige ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ TWITTER: https://twitter.com/Derek_Fitness SNAPCHAT: https://www.snapchat.com/add/derek-fit TIKTOK: https://www.tiktok.com/@moreplates FACEBOOK: https://www.facebook.com/moreplates/ ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

14 Aug 20241h 36min

Are Men Beating Women At The Olympics? - The Truth (comprehensive dissection)

Are Men Beating Women At The Olympics? - The Truth (comprehensive dissection)

📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ TWITTER: https://twitter.com/Derek_Fitness SNAPCHAT: https://www.snapchat.com/add/derek-fit TIKTOK: https://www.tiktok.com/@moreplates FACEBOOK: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #hormones #olympics #boxing ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

12 Aug 202459min

This Is The Power Of Steroids...

This Is The Power Of Steroids...

📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks) 💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order ⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J | discount code "MPMD" for 10% off your entire order 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order 🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order 🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv 🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ THREADS: https://www.threads.net/@moreplatesmoredates FACEBOOK: https://www.facebook.com/moreplates/ SNAPCHAT: https://www.snapchat.com/add/derek-fit TWITTER: https://twitter.com/Derek_Fitness TIKTOK: https://www.tiktok.com/@moreplates ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #bodybuilding #steroids #bodytransformation  ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

3 Jul 202416min

TRT Dosing And Frequency Breakdown With Dr. Peter Attia

TRT Dosing And Frequency Breakdown With Dr. Peter Attia

📌 Check out the full podcast here: https://youtu.be/JNpgqpyzW98 ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: http://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks) 💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order ⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791 🧪 Blood Work: http://bit.ly/2wI3k9J | discount code "MPMD" for 10% off your entire order 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order 🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order 🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): http://bit.ly/2JmpTGv 🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ THREADS: https://www.threads.net/@moreplatesmoredates FACEBOOK: https://www.facebook.com/moreplates/ SNAPCHAT: https://www.snapchat.com/add/derek-fit TWITTER: https://twitter.com/Derek_Fitness TIKTOK: https://www.tiktok.com/@moreplates ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #moreplatesmoredates #peterattia #testosterone   ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

25 Jun 202413min

How To Determine If You Have IFBB Pro Bodybuilder Genetics

How To Determine If You Have IFBB Pro Bodybuilder Genetics

📌 Check out the full podcast here: https://youtu.be/IfRbc1E9boM ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: http://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks) 💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order ⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791 🧪 Blood Work: http://bit.ly/2wI3k9J | discount code "MPMD" for 10% off your entire order 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order 🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order 🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): http://bit.ly/2JmpTGv 🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ THREADS: https://www.threads.net/@moreplatesmoredates FACEBOOK: https://www.facebook.com/moreplates/ SNAPCHAT: https://www.snapchat.com/add/derek-fit TWITTER: https://twitter.com/Derek_Fitness TIKTOK: https://www.tiktok.com/@moreplates ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #stanefferding #bodybuilding #ifbb  ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

9 Jun 20243min

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