How Different Anabolic Steroids Can Affect Your Immune System And Vulnerability To Viral Infections
More Plates More Dates17 Mar 2020

How Different Anabolic Steroids Can Affect Your Immune System And Vulnerability To Viral Infections

Both Testosterone and anabolic androgenic steroids (AAS) adversely influence the immune system, affecting leucocyte growth or activity, and antibody and cytokine production, particularly when used at supraphysiological doses, mimicking a condition of secondary immunodeficiency [R, R]. Secondary immunodeficiency, much more common than primary immunodeficiency (that is to say those caused by genetic defects affecting the cells of the immune system), is characterized by various factors that affect a normal immune system, including infectious, iatrogenic, metabolic and environmental factors. These immune deficiencies are manifested clinically with an increased frequency or unusual complications of common infections and occasionally with the onset of opportunistic pathogen infections. https://youtu.be/ceqSC6GYks4 Nandrolone And Anadrol Effects On The Immune System Nandrolone Decanoate and Anadrol directly induce the production of inflammatory cytokines Interleukin 1 Beta (IL-1β) and Tumor Necrosis Factor Alpha (TNF-α) in human peripheral blood leukocyte cultures [R]. Testosterone and DHEA had no direct cytokine inducing effect in the same model. Nandrolone Decanoate also inhibits interferon production in NDV-infected mouse L-929 and human WISH cells. Winstrol And Trenbolone Effects On The Immune System Winstrol and Trenbolone were found to be genotoxic and cytotoxic to human lymphocytes in a dose dependent manner [R]. Testosterone, Teslac, Anavar And Winstrol Effects On The Immune System To evaluate how anabolic steroids affect the immune system, five commercially available steroids with various types of structural differences were studied in a rodent model [R]. Animals were divided into five groups and treated with Testosterone (group 1), Testosterone Propionate (Group 2), the steroidal aromatase inhibitor Testolactone (Teslac) (Group 3), Anavar (Group 4), and Winstrol (Group 5). Significant immunosuppression was observed with all groups. However, by day 10, the Teslac, Anavar and Winstrol treated group showed immunostimulation and actually exceeded baseline immunity while the Testosterone treated groups maintained immunosuppressed. To truly test the effects of endogenous androgens on the immune system a second experiment was then performed. Ten animals maintained in a similar manner to the initial experiment were either treated intact or were castrated and then treated for 8 days, with Anavar (1.1 mg/kg/day), Testosterone (1.1 mg/kg/day) or Anavar combined with physiologic amounts of Testosterone (15 μg/day). Anavar was selected because it has the greatest anabolic activity of all Testosterone analogues as compared to Testosterone (androgenic/anabolic activity = 1:13). In the intact animals after 8 days of treatment with Anavar, serum Testosterone levels were measured by radioimmunoassay on tail vein blood. Levels were either undetectable or very low, reflecting what would be significant HPTA suppression. Immune function (DCH responses) measured at the same time revealed a 41% increase over baseline. The Testosterone treated group experienced a 36% suppression of immune function. Further treatment for 8 days with Anavar combined with physiologic amounts of Testosterone eliminated the immune system enhancement provided by Anavar monotherapy and returned the DCH responses to levels that were not significantly different from baseline. The results were different in the castrated animals. Castration, resulted in an increase in immune (DCH) responses. The mean observed change was 90% greater than intact (pre-castration) baseline. That means that castrated rats had a 90% improvement above and beyond rats that weren’t castrated. Eight day administration of Anavar to these animals had an immunodepressive effect returning the DCH response to baseline. Eight day treatment with Anavar combined with physiologic doses of Testosterone produced an even greater suppression, 45% change from baseline. These observations indicate that immune alterations do occur with anabolic steroids which are immunosuppressive when the steroid nucleus is intact and immunostimulatory with nuclear alterations. How Steroids Influence Immune Function The hypothesis to explain the immune system responses to steroids is as follows. Exogenous androgenic anabolic steroids produce two effects on the immune system: (A) a direct early effect on immune function which is suppressive and, (B) an indirect delayed stimulatory effect mediated through the negative feedback on the pituitary. (B) results in inhibition of gonadal Testosterone through diminished LH release. A decrease in the synthesis of Testosterone results in low serum Testosterone level and immune stimulation. Castration, by abolishing the modulation of Testosterone secretion eliminates the effect of (B) but leaves (A) intact. In summation, the more suppressive a steroid is the more it can indirectly enhance immune function, simply by suppressing the endogenous production of Testosterone and its metabolites. However, anabolic steroids will also be genotoxic and cytotoxic to human lymphocytes in a dose dependent manner. So, the only reason anabolic steroids can enhance immunity is by being more tissue selective than Testosterone and by shutting down the HPTA, not by inherently being protective. They too will be inherently immunosuppressive, just to a lesser degree based on their tissue selectivity and magnitude of impact on endogenous androgen production suppression. At the end of the day, the data all suggests that the lower your levels of steroids are in the body, the higher level your immune system will function at in parallel. Are You Increasing Your Risk Of Viral Infection When You Are On Cycle? In summary, the vast majority of studies suggest that steroid use decreases antibody formation, Natural Killer (NK) lymphocyte activity, T and B lymphocyte maturation and stimulation resulting in immunosuppression [R]. Supraphysiological doses of common anabolic steroids have been shown to directly influence the production of certain cytokines, altering immune function. The results from both animal and human studies suggest that supraphysiological doses of AAS can negatively impact the immune system. The takeaway from all of this is that with an easily spread virus infecting thousands of people throughout the world right now, it would be prudent to reduce your exogenous AAS use at least down to therapeutic levels to support immune function during this time where having increased vulnerability to viral infection is the most risky. Regardless if you are young and believe you are invincible based on the mortality rate statistics showing that the elderly are the most at risk of being symptomatic or ending up in critical condition, you may still be increasing your chances of becoming an infected carrier who then transmits the virus to the elderly (including your parents or grandparents) as a result of self-induced immunosuppression. Learn more about your ad choices. Visit megaphone.fm/adchoices

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The Conor McGregor Coke Spiral, CTE, And Brain Trauma - With Joe Rogan

The Conor McGregor Coke Spiral, CTE, And Brain Trauma - With Joe Rogan

📌 From JRE # 2239: https://youtu.be/E0mudvCm-bo ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Rigorous Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ Twitter: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

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📌 Check out the full podcast here: https://youtu.be/_PG6sLMuWS8 ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Rigorous Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ Twitter: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

29 Des 202411min

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📌 Check out the full podcast here: https://youtu.be/E0mudvCm-bo ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ Twitter: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

22 Des 20248min

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📌 Check out the full podcast here: https://youtu.be/E0mudvCm-bo ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ Twitter: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

18 Des 20243min

Bryan Johnson's Beef With Elon Musk

Bryan Johnson's Beef With Elon Musk

📌 Check out the full podcast here: https://youtu.be/_PG6sLMuWS8 ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ Twitter: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

18 Des 20247min

The Bryan Johnson Podcast

The Bryan Johnson Podcast

📌 Sponsors To Check Out: 🛌 Eight Sleep - Code "MPMD" will save $200 off the Pod 4, or $350 off the Pod 4 Ultra: https://www.eightsleep.com/moreplatesmoredates/ ⚕️ Marek Health - Preventive Medicine, HRT, & Rigorous Bloodwork Analysis: https://bit.ly/373k791 ———————————— 🕑 Timestamps: 0:00:00 – Intro 0:00:57 – The ‘Rejuvenation Olympics’ Leaderboard 0:02:47 – Who Is Bryan Johnson? 0:09:05 – How Bryan Transitioned From Near-Billionaire Tech Entrepreneur To Experimental Biohacker 0:13:07 – Why Bryan Johnson's Johnson Is The Most Measured Johnson On Earth 0:18:14 – Eight Sleep (The Most Impactful Sleep Enhancing Device I Have Ever Used) 0:21:56 – Erection Quality Metrics And Issues With Tracking 0:23:36 – The Exotic Drugs In Bryan Johnson's "Don't Die" Protocol 0:27:34 – "Don't Die" (but take experimental drugs?) | Grilling Bryan Johnson On His Choice Of Drugs 0:30:58 – Bryan’s View On Hair Transplants, Facial Fillers, Plastic Surgery, Or Anything Surgical That Conflates The Visual Perception Of A Person’s Age 0:33:40 – "HGH Was Catastrophic" | Bryan’s Experience With HGH And Thymus Rejuvenation 0:36:52 – Rapamycin For ‘Anti-Aging’ 0:40:23 – Why Bryan Tried Follistatin Gene Therapy, IV Stem Cells, And Is Using 17α-Estradiol And Metformin 0:45:13 – Power Outage 0:45:14 – Bryan Johnson Risks Ruining His Perfect Sleep Score To Try A Gorilla Mind Energy Drink 0:49:22 – Dissecting The Results Of Bryan Johnson's $25,000 Follistatin Gene Therapy 1:06:38 – What Is Bryan’s ‘Blueprint’ Protocol? 1:15:33 – Bryan Reacts To Elon Musk Saying He Looked Better Before 1:23:54 – Bryan Reacts To Chuando Tan (58 years old) - Does Biohacking Even Work? 1:30:15 – How To Become A Centenarian (100+ Years Old) 1:32:59 – The Most Impactful Of The Exotic Biohacks Bryan Has Tried 1:39:59 – Why Bryan Went On TRT, And Then Came Off 1:44:54 – Does Bryan Have Financial Upside In Any Of The Companies He Promotes That He Hasn’t Explicitly Stated Are His Companies? 1:46:26 – Why 15% Of Bryan’s Daily Calories Come From Extra Virgin Olive Oil (EVOO) 1:48:43 – Diary Of A CEO Podcast Quote About EVOO | “It’s Better Than Ozempic” 1:57:52 – Bryan Psychoanalyzes Me 2:07:11 – Marek Health (Preventive Medicine, HRT, & Rigorous Bloodwork Analysis) 2:13:37 – Bryan Dissects My Mindset 2:16:15 – Determining What Content Creators To Learn From 2:19:11 – The Understanding Of Myostatin Inhibiting Muscle Growth Over The Years 2:22:32 – The Challenges Of Being A Night Owl And Not Sleeping Enough 2:26:01 – Chasing Success, Even When It Starts To Eat Into The Rest Of Your Life 2:32:52 – Imposter Syndrome 2:35:27 – If I Could Change One Thing About How The Medical System Works 2:38:37 – Influencer Burnout 2:40:10 – My Ancestry And Nature Vs. Nurture 2:44:37 – Jordan Peterson's Opinion Of Bryan Johnson’s Life Philosophy 2:53:13 – Thoroughly Dissecting Bryan’s New Supplement Line, His Motivations Behind Starting It, And His Claims Made About Its Efficacy 3:34:36 – Bryan Stating On Diary Of A CEO That Everybody Should Know Their Weight, Speed Of Aging, And Duration Of Nighttime Erections 3:36:33 – The Legitimacy And Utility Of Age Clocks, And When They Can Be Helpful Vs. Harmful 3:58:52 – Bryan’s Use Of Thyroid Hormone Replacement Since He Was 21 Years Old 4:01:14 – Is Drinking Your Own Urine A Dark Horse Biohack? Bryan’s Reaction 4:04:03 – If Bryan Could Go Back In Time Before He Sold His Company For $800 Million, What Would He Tell Himself 4:08:45 – How Does Bryan Factor In Social Loneliness Outranking Essentially Everything For Accelerating Dying ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

14 Des 20244h 14min

"HGH Was Catastrophic" - The Exotic Drugs In Bryan Johnson's "Don't Die" Protocol

"HGH Was Catastrophic" - The Exotic Drugs In Bryan Johnson's "Don't Die" Protocol

📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ Twitter: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

13 Des 202413min

Why Bryan Johnson's Johnson Is The Most Measured Johnson On Earth

Why Bryan Johnson's Johnson Is The Most Measured Johnson On Earth

📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) 💡 https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off ⚕️ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 ———————————— Follow Me On ———————————— Instagram: https://www.instagram.com/moreplatesmoredates/ Twitter: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

12 Des 20246min

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