Diabetes and Epigenetics (Jean-Sébastien Annicotte)

Diabetes and Epigenetics (Jean-Sébastien Annicotte)

Type 2 Diabetes (T2D) is a chronic metabolic disease, which is caused by the failure of beta-cells in the pancreas and insulin resistance in peripheral tissue and characterized by high glucose levels in the blood. World-wide 382 Million people suffer from Diabetes which makes up 8,3% of the population. Due to this high proportion it is of high interest to find a cure for this disease.

The restoration of β-cell mass and function has therefore become a field of intensive research seeking for the next generation of anti-diabetic drugs. Tremendous efforts have been made on deciphering epigenetic regulations that control metabolic tissue function. For several years, the team led by Dr. Jean-Sebastien Annicotte has dissected the molecular links between insulin producing cells, insulin target tissues and T2D/obesity development. Especially, the team research has been focused on the role of cell cycle regulators and their transcriptional co-regulators in the control of metabolic homeostasis, T2D and obesity.

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Episoder(167)

Taking ChIP from Yeast to ENCODE to Enable Genome-Wide Regulatory Protein Mapping (Peggy Farnham)

Taking ChIP from Yeast to ENCODE to Enable Genome-Wide Regulatory Protein Mapping (Peggy Farnham)

In this episode of the Epigenetics Podcast, we talked with Peggy Farnham from the Keck School of Medicine at USC about her work on establishing the ChIP Method in mammalian cells. In this episode, we ...

29 Jan 29min

Spatial-Omics and Machine Learning in Muscle Stem Cell Repair (Will Wang)

Spatial-Omics and Machine Learning in Muscle Stem Cell Repair (Will Wang)

In this episode of the Epigenetics Podcast, we talked with Will Wang from Sanford Burnham Prebys about his work on muscle stem cell repair, regeneration, and aging, exploring spatial-omics and machine...

15 Jan 55min

The Future of Protein–DNA Mapping (Mitch Guttman)

The Future of Protein–DNA Mapping (Mitch Guttman)

In this episode of the Epigenetics Podcast, we talked with Mitch Guttman from Caltec about ChIP-DIP (ChIP-Done In Parallel). ChIP-DIP is a newly developed approach for high-resolution protein–DNA inte...

18 Des 20251h 2min

Chromatin Modifiers and Their Roles in Brain Development (Fides Zenk)

Chromatin Modifiers and Their Roles in Brain Development (Fides Zenk)

In this episode of the Epigenetics Podcast, we talked with Fides Zenk from the École polytechnique fédérale de Lausanne about her work on transgenerational inheritance in Drosophila and brain organoid...

4 Des 202528min

Region Capture Micro-C and 3D Genome Structure (Anders Sejr Hansen)

Region Capture Micro-C and 3D Genome Structure (Anders Sejr Hansen)

In this episode of the Epigenetics Podcast, we talked with Anders Sejr Hansen from MIT about his work on the impact of 3D genome structures on gene expression, the roles of proteins like CTCF and cohe...

13 Nov 20251h 3min

Reprogramming Cell Identity through Epigenetic Mechanisms (Vincent Pasque)

Reprogramming Cell Identity through Epigenetic Mechanisms (Vincent Pasque)

In this episode of the Epigenetics Podcast, we talked with Vincent Pasque from KU Leuven about his work on the reprogramming of cell identity through epigenetic mechanisms, particularly during early d...

30 Okt 202540min

The Impact of Chromatin Architecture on Alzheimer's and Parkinson's Disease (Ryan Corces)

The Impact of Chromatin Architecture on Alzheimer's and Parkinson's Disease (Ryan Corces)

In this episode of the Epigenetics Podcast, we talked with Ryan Corces from the Gladstone Institutes about his work on the impact of chromatin architecture on Alzheimer's and Parkinson's Disease. The...

16 Okt 202545min

RNA-Mediated Epigenetic Regulation (Mo Motamedi)

RNA-Mediated Epigenetic Regulation (Mo Motamedi)

In this episode of the Epigenetics Podcast, we talked with Mo Motamedi from the Center for Cancer Research at Massachusetts General Hospital about his work on RNA-mediated epigenetic regulation. The I...

2 Okt 202545min

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