#359 Reversing Biological Aging and Extending Lifespan - Matt Kaeberlein PhD

#359 Reversing Biological Aging and Extending Lifespan - Matt Kaeberlein PhD

Welcome to the Siim Land podcast. I’m your host Siim Land and our guest today is Matt Kaeberlein. Matt is a Phd and researcher in the biology of aging. He’s one of the world’s most renown names in longevity, life extension and healthy aging.

Head over to biohackercenter.com and use the code SIIMLAND for a 10% discount.

Timestamps: 01:00 Changes in Aging Research Over the Past Decades 05:00 Is Aging a Modifiable Program 08:45 How Long Can Humans Live 11:13 Genetic Engineering for Longevity 13:03 Why Do Some People Live Over 100 18:20 Lifestyle Factors That Extend Lifespan 24:10 Calorie Restriction for Living Longer 28:22 Prolonged Calorie Restriction in Humans 30:39 Food Quality and Calorie Restriction Diet 34:05 Intermittent Fasting and Time Restricted Eating 40:12 Calorie Restriction Mimetics 43:00 Rapamycin Research 50:30 Dog Rapamycin Study 54:05 Are Biological Age Tests Accurate 01:02:40 Is Age Reversal Possible 01:11:25 Risk of Low Protein Diets


Episoder(490)

#443 Physionic on Longevity, Autophagy, Supplements, and More

#443 Physionic on Longevity, Autophagy, Supplements, and More

Get Bon Charge red light therapy for 15% off: https://boncharge.com/pages/siimlandTimestamps: 00:38 Nick’s PhD and autophagy research 02:33 What is autophagy 03:53 Autophagy and longevity 08:05 Bon Charge Sponsorship 08:55 Where autophagy comes from 11:40 What triggers autophagy 18:15 mTOR and longevity 20:15 Should you eat a lower protein diet 25:45 Supplements for autophagy 28:35 Metformin 32:35 Acarbose 34:25 Rapamycin 36:35 Speed of aging tests 43:00 Longevity supplements 50:05 Nick’s opinions on diet 56:35 Nick’s nutrition, exercise and supplement plan 01:01:10 Importance of sleepPhysionic YouTube channel: https://www.youtube.com/@Physionic/

7 Mar 1h 7min

#442 Regenerative Doctor on How to Fix Joint Pain Without Surgery - Dr David Karli

#442 Regenerative Doctor on How to Fix Joint Pain Without Surgery - Dr David Karli

BioPrime oral BPC157 with code SIIM10 for 10% discount - Get 3 month supply for best effects: https://www.bioprimesupplements.com/index.php?route=product%2Fproduct&product_id=53&tracking=g8PrbVPWwr3K1a42mbbnslSqmty6fFgjT3YxDU0MAXwf18eL4MBMHgSQgFBSv3FrTimestamps:00:25 Dr Karli’s training in cell therapies07:00 BioPrime Supplements Sponsorship07:55 Why do people develop pain disorders10:00 Importance of exercise for orthopedic longevity14:30 Injuries from exercise19:30 Does nutrition play a role in joint disorders23:40 Stem cells for orthopedics35:30 Converging functional medicine and regenerative medicine42:05 When do you need surgery44:25 PRP – platelet rich plasma48:10 PRP and stem cells for prevention54:10 Peptides for joints59:40 Rapid fire round: which joint problem which therapy 01:07:40 Daily exercises to prevent joint painDr David Karli Instagram: https://www.instagram.com/davidkarli/

26 Feb 1h 12min

#441 How to Balance Your Nervous System for Optimal Health - Dr Mark Atkinson

#441 How to Balance Your Nervous System for Optimal Health - Dr Mark Atkinson

Get Bon Charge red light therapy for 15% off: https://boncharge.com/pages/siimlandTimestamps: 00:41 Mark’s backstory 05:41 How the body and mind connected 11:40 How to balance your nervous system 20:30 How to stimulate the vagus nerve 23:10 Nutrition and gut health 27:10 Blood markers for stress 30:00 You need to focus on both mental and physical health 40:20 How to deal with health anxiety 46:30 Mark’s free webinar 49:35 Core pillars of thriving as a humanDr Mark's Free Webinar Thrive Essentials: https://theschoolofbiohacking.com/programs/thrive-essentials/ref/5/

22 Feb 58min

#440 GENETICS Based Supplements You Should AVOID - Dr Tyler Panzner

#440 GENETICS Based Supplements You Should AVOID - Dr Tyler Panzner

Timestamps: 00:00 Introduction 01:40 How Tyler Got Into Genetics 07:00 How Genes Affect Caffeine Metabolism 14:35 Creatine and Genetics 22:40 Citrulline and Arginine 27:35 Glycine 32:35 Histamine, Fermented Foods, Bone Broth 37:20 Food Sensitivities and Plant Chemicals 41:00 Methylation 44:05 Microplastics 48:40 Melatonin 54:30 Vitamin D 59:55 Omega-3s 01:04:40 Where to Start Understanding Your Genetics 01:08:30 Food Allergy TestingDr Tyler Panzner Instagram: https://www.instagram.com/drtylerpanzner/Dr Tyler Panzner website: https://drtylerpanzner.com/

15 Feb 1h 10min

#439 How Stress Resilience Makes You Live Longer - Dr Olli Sovijärvi

#439 How Stress Resilience Makes You Live Longer - Dr Olli Sovijärvi

Get Olli's and My Longevity Books (Code SIIMLAND for a 15% discount): https://biohackercenter.com/collections/books-longevity-biohackingTimestamps:00:18 Overlap Between Resilience and Longevity09:48 Hormesis and Adaptation14:48 Voluntarily Exposing Yourself to Stress20:18 Sauna Benefits32:43 Contrast Therapy with Sauna and Cold34:08 Benefits of Cold Exposure43:23 How to Track Your Response to Stress49:23 Vagus Nerve and Nervous System57:13 Exercise and Stress Resilience01:03:08 Olli’s Top 3 Adaptogens01:13:08 Plant Defense ChemicalsOlli Sovijärvi Instagram: https://www.instagram.com/ollisovijarvi/

9 Feb 1h 28min

#437 The Ambitious 3 Step Plan to Solving Aging and Death - Nathan Cheng

#437 The Ambitious 3 Step Plan to Solving Aging and Death - Nathan Cheng

Order my new book: https://www.amazon.com/dp/B0CW1B2XM1 Timestamps: 00:00 Intro 00:21 Why Nathan Dropped Out of His PhD Thesis to Pursue Longevity Research 07:51 Roadmap to Extending Human Lifespan 12:41 Body Replacement 18:33 Organ Cloning 26:11 Brain Replacement 33:36 Cyborg Organs 36:38 Pausing Aging in the Body 45:58 Bioengineering and Gene Therapy 56:36 Vitalism Nathan Cheng X: https://x.com/realNathanCheng

1 Feb 1h 20min

#438 Skin Anti-Aging Masterclass with Dr Alexis Ortega

#438 Skin Anti-Aging Masterclass with Dr Alexis Ortega

Get Bon Charge infrared sauna blanket 15% off: https://boncharge.com/pages/siimland Timestamps: 00:00 Intro 00:30 Why Skin Anti-Aging Matters 02:15 What Everyone Should Do for Skin Anti-Aging 06:25 Bon Charge Sponsorship 07:12 Skin Aging Analysis Techniques 12:15 Pores and Cleaning the Skin 15:25 Three Basic Products Alexis Gives His Patients 20:55 Best Sunscreens to Take 37:30 Retinol 48:15 Microneedling 53:05 Red Light Therapy and Lasers 01:02:35 Botox 01:08:35 Exosomes 01:14:15 Moisturizers 01:17:40 Copper Peptide GHK-Cu 01:23:00 Niacinamide 01:24:55 Skin anti-aging supplements 01:34:55 Final words Alexis Ortega MD Instagram: https://www.instagram.com/alexis_ortega_md/

1 Feb 1h 37min

#436 Is Methylene Blue the Magic Bullet for Health? - Dr Scott Sherr

#436 Is Methylene Blue the Magic Bullet for Health? - Dr Scott Sherr

Get Bon Charge infrared sauna blanket 15% off: https://boncharge.com/pages/siimland Timestamps: 00:00 Introduction 00:30 What Is Methylene Blue 05:35 Methylene Blue Antiviral Effects 12:55 Methylene Blue Effects on Mitochondrial Function 17:55 Is Methylene Blue and Oxygen 24:30 Methylene Blue for Exercise 26:10 Nitric Oxide 31:25 Does Methylene Blue Have Longevity Benefits 39:50 Skin Anti-Aging Effects 43:30 Safety 48:50 Nootropic Effects 52:05 Right Dosage Dr Scott Sherr Instagram: https://www.instagram.com/drscottsherr/

18 Jan 59min

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