Podcast #199: Prolonged QT with Zofran

Podcast #199: Prolonged QT with Zofran

Author: Arthur Lessen M.D.

Educational Pearls:

  • Zofran (ondansetron) is generally safe to use for the treatment of nausea and vomiting. However, it can prolong the QT interval and increase the chance for torsades.

  • Low doses of Zofran are not likely to be an issue. However, when multiple doses are given, especially in the setting of a preexisting LQTS, clinical concern should be raised.
  • When giving Zofran to a patient with an increased risk for torsades, consider continuous cardiac monitoring or an alternate anti-emetic.

References: https://www.fda.gov/Drugs/DrugSafety/ucm310190.htm

Episoder(1146)

Podcast # 343: Snake Bites

Podcast # 343: Snake Bites

Educational Pearls: Snake bites commonly occur between April and October. Rattlesnake bites are the most common. Venom contains proteins/enzymes that cause local inflammation, coagulopathy, and...

20 Jun 20186min

Podcast # 342: Scombroid

Podcast # 342: Scombroid

Author: Jared Scott, MD Educational Pearls: Scombroid is a type of food poisoning associated with dark fish (i.e. tuna, salmon, mackerel) that mimics anaphylaxis. Occurs through conversion of histi...

18 Jun 20184min

Podcast # 341: Tenecteplase vs. Alteplase

Podcast # 341: Tenecteplase vs. Alteplase

Author: Rachel Beham, PharmD Educational Pearls: Tenecteplase is more specific for fibrin and has a longer half-life than alteplase. In setting of ischemic stroke, tenecteplase before thrombectomy ...

13 Jun 20183min

Podcast # 340: Drowning

Podcast # 340: Drowning

Author: Chris Holmes, MD Educational Pearls: Epidemiology: 80% male, ages 1-4 at greatest risk, African-American > Caucasian. Freshwater and ocean water may have more bacteria than pool water. ...

11 Jun 20185min

Podcast # 339: Ectopic Pregnancy Risk Factors

Podcast # 339: Ectopic Pregnancy Risk Factors

Author: Jared Scott, MD Educational Pearls: Data is mixed, but some studies show 1-2% of pregnancies are ectopic. Risk factors for ectopic pregnancies include: pelvic inflammatory disease, prior ec...

8 Jun 20185min

Podcast # 338: Mononucleosis predictors

Podcast # 338: Mononucleosis predictors

Author: Chris Holmes, MD Educational Pearls: Symptoms commonly seen with mononucleosis are palatal petechiae, posterior cervical lymphadenopathy, inguinal/axillary lymphadenopathy, splenomegaly, and/...

6 Jun 20182min

Podcast # 337: Airway Burn Inhalation

Podcast # 337: Airway Burn Inhalation

Author: John Winkler, MD Educational Pearls: Singed nasal hairs, soot around mouth, hoarse voice, drooling, and burns to head/face are signs suggestive of inhalation injury. Early intubation is cri...

4 Jun 20186min

Podcast # 336: Hypokalemia

Podcast # 336: Hypokalemia

Author: Dylan Luyten, MD Educational Pearls:   Most important questions to answer with low potassium are 1. What are their symptoms? 2. Can they take potassium by mouth? Oral repletion is faster, c...

31 Mai 20183min

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