Podcast # 341: Tenecteplase vs. Alteplase

Author: Rachel Beham, PharmD

Educational Pearls:

• Tenecteplase is more specific for fibrin and has a longer half-life than alteplase.
• In setting of ischemic stroke, tenecteplase before thrombectomy was associated with a statistically higher incidence of reperfusion and better functional outcome than alteplase.

References

Bruce C.V. Campbell B et al (2018). Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke. New England Journal of Medicine. 378:1573-1582