Podcast 539:  Coricidin Abuse

Podcast 539: Coricidin Abuse

Contributor: Rachel Beham, PharmD

Educational Pearls:

  • Coricidin HBP Cough & Cold (dextromethorphan and chlorpheniramine) is one of the more commonly abused over-the-counter medications
  • Dextromethorphan, binds to multiple receptors, particularly at high doses
    • Opioid receptors, causing respiratory depression, CNS depression
    • NMDA receptors, causing agitation and hallucinations
    • Serotonin-reuptake inhibition, which may lead to serotonin syndrome, especially when combined with other agents
  • Dextromethorphan also contains bromide, which when chronically abused can lead to bromism (behavioral changes, hallucinations, weight loss, and neurologic changes)
  • Chlorpheniramine is an antihistamine and can cause anticholinergic effects in overdose, such agitation, hyperthermia, and hallucinations
  • Acute treatment of Coricidin abuse is mostly supportive, which may include benzodiazepines, naloxone, dialysis, sodium bicarbonate, and physostigmine depending on the predominate toxidrome and symptoms present

References

Ritter D, Ouellette L, Sheets JD, Riley B, Judge B, Cook A, Houseman J, Jones JS. "Robo-tripping": Dextromethorphan toxicity and abuse. Am J Emerg Med. 2019 Nov 17. pii: S0735-6757(19)30655-2. doi: 10.1016/j.ajem.2019.10.001.

Bryner JK, Wang UK, Hui JW, Bedodo M, MacDougall C, Anderson IB. Dextromethorphan abuse in adolescence: an increasing trend: 1999-2004. Arch Pediatr Adolesc Med. 2006;160(12):1217–1222. doi:10.1001/archpedi.160.12.1217

Monks S, Yen M, Myers J. Bromism: An overlooked and elusive toxidrome from chronic dextromethorphan abuse. Am J Emerg Med. 2019 Nov 15:158491. doi: 10.1016/j.ajem.2019.158491.

Summarized by Will Dewispelaere, MS4 | Edited by Erik Verzemnieks, MD



Episoder(1147)

UnfilterED #10: Debi Smith

UnfilterED #10: Debi Smith

General Counsel attorney, Debi Smith, joins Dr. Nick Tsipis to discuss the ins and outs of healthcare law. Many people forget that a subpoena only compels attendance to a court date, it does not compe...

23 Sep 202024min

Podcast 598: Sepsis, Round One

Podcast 598: Sepsis, Round One

Contributor: Aaron Lessen, MD Educational Pearls: Early antibiotics have been shown to improve outcomes in septic patients time after time Emerging evidence challenges the concept of one-size-fits-al...

22 Sep 20203min

Podcast 597: Weather Can be a Headache

Podcast 597: Weather Can be a Headache

Contributor: Sam Killian, MD Educational Pearls: One study found that patients presented with headaches more frequently when there was high temperatures and low humidity, while higher humidity is cor...

21 Sep 20202min

Pediatric Emergencies Brewcast: Pediatric Trauma

Pediatric Emergencies Brewcast: Pediatric Trauma

Emergency Medical Minute collaborated with CarePoint Health in early March for a night of education on Pediatric Emergencies at a local Denver brewery for our latest Brewcast. Pediatric patients requi...

16 Sep 202024min

Podcast 596: Peripheral Vasopressors

Podcast 596: Peripheral Vasopressors

Contributor: Aaron Lessen, MD Educational Pearls: Traditional teaching has shied away from using vasopressors through peripheral IVs Tissue necrosis from extravasation is cited as a risk of use of va...

15 Sep 20203min

Podcast 595: Smoking. Still Bad

Podcast 595: Smoking. Still Bad

Contributor: Don Stader, MD Educational Pearls: On average, smoking reduces life expectancy by 13.2 years for men and for 14.5 years for women Nicotine is highly addictive and has both stimulant and ...

14 Sep 20203min

On The Streets #8: Limb Injury and Preservation

On The Streets #8: Limb Injury and Preservation

Dr. Glenda Quan, esteemed Trauma Surgeon at Swedish Medical Center, discusses cases related to limb injury and reviews their management. Topics include proper tourniquet application as well as altern...

9 Sep 202024min

Podcast 594: Topicalization for Awake Intubations

Podcast 594: Topicalization for Awake Intubations

Contributor: Ricky Dhaliwal, MD, JD Educational Pearls: Topical anesthetization can allow for an awake intubation, which substantially decreases chance of loss of airway or respiratory drive because ...

8 Sep 20203min

Populært innen Vitenskap

fastlegen
rekommandert
tingenes-tilstand
rss-rekommandert
jss
liberal-halvtime
villmarksliv
rss-paradigmepodden
forskningno
sinnsyn
fjellsportpodden
pod-britannia
nevropodden
rss-nysgjerrige-norge
tidlose-historier
hva-er-greia-med
diagnose
rss-overskuddsliv
smart-forklart
rss-lundqvist-podden