Podcast 601: Droperidol

Podcast 601: Droperidol

Contributor: Sam Killian, MD

Educational Pearls:

  • Droperidol (Inapsine) is an antipsychotic drug with efficacy for nausea, vomiting, headaches, and treating agitation
  • In the early 2000's, Droperidol received a black box warning for QT prolongation
  • This caused a precipitous drop of in administration and ultimately led to a stop in production
  • More careful analysis since has called into question the true incidence of QT prolongation in typical dosing
  • Retrospective review published this year looked at 15,374 non-critical and 1,172 critical patients who received droperidol with only a single episode of Torsades des pointes (which was attributed to multiple other risk factors)
  • Of the 2,431 non-critical patients, and 396 critical patients, who received an ECG before and after administration, there were no changes to the mean QTc
  • Droperidol is being manufactured again and the prior black box warning being called into question, so it will likely begin to become more widely available for use

References

Cole JB, Lee SC, Martel ML, Smith SW, Biros MH, Miner JR. The Incidence of QT Prolongation and Torsades des Pointes in Patients Receiving Droperidol in an Urban Emergency Department. West J Emerg Med. 2020 Jul 2;21(4):728-736. doi: 10.5811/westjem.2020.4.47036. PMID: 32726229; PMCID: PMC7390553.

Perkins J, Ho JD, Vilke GM, DeMers G. American Academy of Emergency Medicine Position Statement: Safety of Droperidol Use in the Emergency Department. J Emerg Med. 2015 Jul;49(1):91-7. doi: 10.1016/j.jemermed.2014.12.024. Epub 2015 Mar 30. PMID: 25837231.

Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD



Episoder(1145)

Deep Dive #6: Bacteriuria and the Elderly

Deep Dive #6: Bacteriuria and the Elderly

Author: Heidi Wald, MD, MSPH Associate Professor of Medicine - University of Colorado School of Medicine, Physician Advisor - Colorado Hospital Association Dr. Heidi Wald explains common misconceptio...

25 Sep 201729min

Podcast #255: Posterior Vitreous Detachment

Podcast #255: Posterior Vitreous Detachment

Author: Erik Verzemnieks, M.D. Educational Pearls Posterior vitreous detachment is the tearing of the lining in the back of of the eye. Patients often present with loss of vision and floaters. Diagno...

22 Sep 20171min

Podcast #254: Myths About Antibiotic Course Length

Podcast #254: Myths About Antibiotic Course Length

Author: Chris Holmes, M.D. Educational Pearls There's little/no data about the necessary length of an antibiotic course, nor has it proven that stopping a course of antibiotics early selects for the ...

20 Sep 20174min

Podcast #253: Total Eclipse of the Eye - Solar Retinopathy

Podcast #253: Total Eclipse of the Eye - Solar Retinopathy

Author: Nick Hatch, M.D. Educational Pearls Photic or solar retinitis occurs when you stare at the sun. The refractive power of the lens of the eye concentrates the light of the sun on the retina, st...

18 Sep 20173min

Podcast #252: Mandible Fractures

Podcast #252: Mandible Fractures

Author: Sam Killian, M.D. Educational Pearls The tongue blade test is done for mandible fractures, which make up 40-60% of facial fractures. The test is done by having the patient bite down on a tong...

15 Sep 20174min

Podcast #251: Cyanide Poisoning

Podcast #251: Cyanide Poisoning

Author: Rachel Beham, PharmD, Advanced Clinical Pharmacist – Emergency Medicine Educational Pearls Cyanide poisoning is suspected in patients who present with lactic acidosis after being trapped arou...

13 Sep 20174min

Podcast #250: Desmopressin

Podcast #250: Desmopressin

Author: Rachael Duncan, PharmD BCPS BCCCP Educational Pearls Desmopressin is an ADH mimetic and helps retain water, release von Willibrand Factor (in high doses), and treat diabetes insipidus (in low...

11 Sep 20173min

Podcast #249: Detecting Pulses

Podcast #249: Detecting Pulses

Author: Jared Scott, M.D. Educational Pearls Overall, medical providers are bad at detecting pulses. However, only 2% of patients do not have a detectable DP pulse. In one study, for patients with l...

10 Sep 20173min

Populært innen Vitenskap

fastlegen
tingenes-tilstand
rekommandert
jss
rss-nysgjerrige-norge
rss-rekommandert
sinnsyn
forskningno
rss-paradigmepodden
villmarksliv
vett-og-vitenskap-med-gaute-einevoll
fjellsportpodden
nordnorsk-historie
smart-forklart
rss-overskuddsliv
diagnose
abid-nadia-skyld-og-skam
aldring-og-helse-podden
pod-britannia
tidlose-historier