Podcast 637: LSD

Podcast 637: LSD

Contributor: Katie Sprinkel, MD

Educational Pearls:

  • Commonly known as "acid," LSD is seeing a resurgence in the population as a recreational hallucination
  • Onset is about 30 minutes with peak pharmacologic effects at 2-4 hours, the drug's half life is 3 hours resulting in some prolonged effects
  • While there is not an significant addictive component of LSD, tolerance for LSD does occur and prolonged usage is associated with increased incidence of schizophreniform disorders
  • Hallucinations and pseudo-hallucinations (sensory misperceptions) are typical of LSD intoxication, other common signs of intoxication include nausea, diaphoresis, tachycardia, mydriasis, and hypertension
  • More serious effects can be coma, hyperthermia, seizures, cardiac arrest, serotonin syndrome (with concomitant SSRI use) and coagulopathy, although the dose to cause these effects is very high
  • Treatment is decreasing sensory stimulation, benzodiazepines in some cases, and symptomatic treatment - no specific antidote exists

References

Blaho K, Merigian K, Winbery S, Geraci SA, Smartt C. Clinical pharmacology of lysergic acid diethylamide: case reports and review of the treatment of intoxication. Am J Ther. 1997 May-Jun;4(5-6):211-21. doi: 10.1097/00045391-199705000-00008. PMID: 10423613.

Klock JC, Boerner U, Becker CE. Coma, hyperthermia and bleeding associated with massive LSD overdose. A report of eight cases. West J Med. 1974;120(3):183-188.

Summarized by John Spartz, MS3 | Edited by Erik Verzemnieks, MD



Episoder(1146)

On the Streets #5: Trauma during COVID-19

On the Streets #5: Trauma during COVID-19

Jordan sits down to discuss trauma with Dr. Kaysie Banton, the Trauma Services Medical Director at Level 1 Trauma Center Swedish Medical Center in Englewood, Colorado. In this laid back interview, Dr....

20 Mai 202026min

Podcast 564:  Cardiac Ischemia Management Update

Podcast 564: Cardiac Ischemia Management Update

Contributor: Nick Tsipis, MD Educational Pearls: Recent randomized controlled trial compared early intervention (PCI/CABG) to medical management for those diagnosed with moderate to severe cardiac is...

19 Mai 20205min

Podcast 563:  DC ACs

Podcast 563: DC ACs

Contributor: Nick Hatch, MD Educational Pearls: An AC (acromioclavicular joint) separation in the shoulder is a common traumatic injury XRs can help rule out other injuries as well as help with gradi...

18 Mai 20202min

COVID-19 Digest: Could Cigarette Smoking Actually be Protective Against COVID?

COVID-19 Digest: Could Cigarette Smoking Actually be Protective Against COVID?

Host: Elizabeth Esty, MD. Smoking is known to increase both susceptibility and severity of all manner of colds and pneumonias, so you'd think the world's 1.1 billion smokers would be at risk in this p...

13 Mai 202018min

Podcast 562:  COVID-19 Occlusions

Podcast 562: COVID-19 Occlusions

Contributor: Nick Tsipis, MD Educational Pearls: Case series reported 5 cases of generally young and healthy patients with COVID-19 who presented to the ER with acute stroke Now several case series s...

12 Mai 20202min

Podcast 561:  Give Bup

Podcast 561: Give Bup

Contributor: Don Stader, MD Educational Pearls: Buprenorphine has been shown to decrease morbidity and mortality in opioid use disorder Buprenorphine used in naloxone-induced withdrawals can displace...

11 Mai 20204min

COVID-19 Digest: Bacille Calmette-Guérin (BCG) Vaccine for Treating COVID-19

COVID-19 Digest: Bacille Calmette-Guérin (BCG) Vaccine for Treating COVID-19

In the US, few people receive vaccination for tuberculosis (TB), a disease that hasn't been a major killer here for many decades. But while we in the US mostly experience TB as a relatively rare but ...

8 Mai 202014min

Podcast 560:  Imaging in a COVID world

Podcast 560: Imaging in a COVID world

Contributor: Don Stader, MD Educational Pearls: COVID-19 commonly appears as a bilateral patchy infiltrate on chest radiograph, but this is a non-specific finding Sensitivities range from 17-70% f...

7 Mai 20206min

Populært innen Vitenskap

fastlegen
rekommandert
tingenes-tilstand
jss
rss-rekommandert
liberal-halvtime
villmarksliv
forskningno
sinnsyn
fjellsportpodden
rss-paradigmepodden
nevropodden
rss-nysgjerrige-norge
tidlose-historier
vett-og-vitenskap-med-gaute-einevoll
diagnose
smart-forklart
pod-britannia
dekodet-2
hva-er-greia-med