Effect of therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam in sepsis patients
ESICM Talk2 Mar 2022

Effect of therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam in sepsis patients

Growing evidence suggests that insufficient antibiotic exposure (defined as failure to achieve the pharmacokinetic/pharmacodynamic (PK/PD) target to kill or inhibit the growth of a pathogen) is associated with worse clinical outcomes in sepsis patients.

Moreover, up to 50% of critically ill patients receiving a β-lactam antibiotic with regimens based on manufacturers' recommendations fail to reach the target.

Therapeutic drug monitoring (TDM)-guided therapy has been proposed as a strategy to further optimise the achievement of the PK/PD target of β-lactam antibiotics. However, there are no data on whether piperacillin/tazobactam TDM can improve clinical outcomes.

In this context, a large RCT was performed to investigate whether TDM-based dose optimisation versus fixed dosing could improve clinical outcomes in patients with sepsis treated with piperacillin/tazobactam as a continuous infusion.

Dr Hagel shares with us the results of this study published in the ICM Journal.

Original study:

Hagel S et al. Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial. Intensive Care Med. 2022 Mar;48(3):311-321. doi: 10.1007/s00134-021-06609-6

Speakers

Stefan HAGEL. Assistant medical director and consultant at the Institute for Infectious Diseases and Infection Control and Center for Sepsis Control and Care at the Jena University Hospital (DE).

Laura BORGSTEDT. Department of Anesthesiology, Klinikum rechts der Isar, Technical University of Munich, Munich (DE).

Episoder(91)

Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes

Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Despite progress in the understanding of sepsis pathophysiology, no specific treatment has proven...

20 Mar 202419min

ECMO PAL: using deep neural networks for survival prediction in venoarterial extracorporeal membrane oxygenation

ECMO PAL: using deep neural networks for survival prediction in venoarterial extracorporeal membrane oxygenation

VA-ECMO outcome scores have been previously developed and used extensively for risk adjustment, patient prognostication, and quality control across time and centres. The limitation of such scores is t...

6 Mar 202411min

Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting

Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting

Numerous Population Pharmacokinetic (PopPK) models have been developed for Piperacillin (PIP), most of which are based on small monocentric studies and may not be generalizable to other populations. A...

14 Feb 202417min

Green ICU - Environmental Sustainability in intensive care

Green ICU - Environmental Sustainability in intensive care

The concept of a "green ICU" is increasingly important in today's world, as sustainability and environmental considerations become integral to healthcare practices. Hospitals, including ICUs, can have...

7 Feb 202412min

Diving into ARDS with Prof. Gattinoni. From the new guidelines to bedside applied physiology.

Diving into ARDS with Prof. Gattinoni. From the new guidelines to bedside applied physiology.

Acute respiratory distress syndrome (ARDS) is the term applied to a spectrum of conditions with different etiologies that share common clinical-pathological characteristics including: increased perme...

20 Des 202339min

Sepsis-associated acute kidney injury in the intensive care unit. A multicenter observational study

Sepsis-associated acute kidney injury in the intensive care unit. A multicenter observational study

Sepsis‐associated acute kidney injury (SA‐AKI) is a common, increasingly prevalent problem in the intensive care unit (ICU). The association between sepsis and AKI has been studied previously. However...

8 Nov 202315min

Patient Transportation in Critical Care: introduction to our ACE course

Patient Transportation in Critical Care: introduction to our ACE course

Transportation of critically ill patients is inevitable in most health systems. Prehospital transportation (PHT) may be necessary after a major injury or as a result of a life-threatening illness – fo...

4 Okt 202312min

Interprofessional teamwork in ICU

Interprofessional teamwork in ICU

Intensive care units (ICU) are the most peculiar units in hospitals where the quality and safety of health care delivery should be at the highest level. The most critical patients are treated in this ...

27 Sep 202324min

Populært innen Business og økonomi

lydartikler-fra-aftenposten
stopp-verden
dine-penger-pengeradet
e24-podden
rss-penger-polser-og-politikk
rss-borsmorgen-okonominyhetene
livet-pa-veien-med-jan-erik-larssen
pengepodden-2
pengesnakk
utbytte
tid-er-penger-en-podcast-med-peter-warren
finansredaksjonen
morgenkaffen-med-finansavisen
rss-sunn-okonomi
liberal-halvtime
rss-politisk-preik
lederpodden
okonomiamatorene
stormkast-med-valebrokk-stordalen
rss-markedspuls-2