The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS
Recent evidence suggests that acute hypercapnia could have harmful physiological and clinical effects in patients with ARDS, particularly impacting the haemodynamic system. A review and meta-analysis ...
25 Mai 202211min
Sepsis hospitalisation and risk of subsequent cardiovascular events in adults
Sepsis refers to a dysregulated response to infection-causing end-organ dysfunction. It is associated with short-term risks such as shock and in-hospital death. Meanwhile, long-term consequences among...
13 Apr 202215min
Prophylactic melatonin for delirium in intensive care (Pro-MEDIC)
Delirium is a condition of acute organic brain dysfunction with fluctuating disturbances of attention and cognition, and its prevalence in intensive care units (ICUs) is recorded as high as 80%.Deliri...
6 Apr 202213min
Role of pre-clinical experimentation in intensive care: from ethical to clinical practice
Preclinical studies precede most clinical trials. They help identify criteria for evaluating human safety, including signs and symptoms that should be monitored closely during early clinical trials.Th...
23 Mar 202232min
ERC-ESICM guidelines on temperature control after cardiac arrest in adults
The aim of the ERC-ESICM guidelines on temperature control after cardiac arrest in adults is to provide evidence-based guidance in adults who are comatose after resuscitation from either in-hospital o...
9 Mar 202215min
Effect of therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam in sepsis patients
Growing evidence suggests that insufficient antibiotic exposure (defined as failure to achieve the pharmacokinetic/pharmacodynamic (PK/PD) target to kill or inhibit the growth of a pathogen) is associ...
2 Mar 202229min
Current practice and evolving concepts in septic shock resuscitation
Clinical and pathophysiological understanding of septic shock has progressed exponentially in the previous decades, translating into a steady decrease in septic shock-related morbidity and mortality. ...
16 Feb 202222min
