Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes
ESICM Talk20 Mar 2024

Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Despite progress in the understanding of sepsis pathophysiology, no specific treatment has proven successful. The precision therapy, a greater understanding of the heterogeneity of sepsis is needed.

Recent approaches to measuring sepsis heterogeneity used unsupervised computational methods on clinical, biomarker, or gene expression data from observational studies or clinical trial datasets. At present, more than 100 sepsis subtypes are proposed, without awareness of overlap (or clinical implications). It is unknown whether each new subtype strategy is an added value for the patient.

To address this knowledge gap, a study was conducted aiming to determine the concordance between different sub-type labels, outcomes, and biologic pathways of critically ill sepsis patients classified by previously proposed sepsis subtyping methods. Listen to the podcast and learn more about the methodology and findings of this study.

Episoder(90)

ARDS Phenotyping: from disease understanding to future bedside perspectives

ARDS Phenotyping: from disease understanding to future bedside perspectives

To date, no specific pharmacotherapy has proven effective against acute respiratory distress syndrome ARDS. Results on the research domain have been ineffective in human trials, a gap attributed in pa...

19 Jun 202446min

Mechanical circulatory support for cardiogenic shock: a network meta-analysis of randomized controlled trials and propensity score-matched studies

Mechanical circulatory support for cardiogenic shock: a network meta-analysis of randomized controlled trials and propensity score-matched studies

Cardiogenic shock accounts for up to 5% of acute heart failure presentations and around 14–16% of patients reported in cardiac intensive care datasets. It complicates up to 15% of all myocardial infar...

12 Jun 202441min

N&AHP – ICU diaries

N&AHP – ICU diaries

The communication between families of critically ill patients who manifest prolonged disturbances in the consciousness such as patients under sedation, in a coma, or delirium, and the caregivers becam...

22 Mai 202420min

Burned out in ICU professionals

Burned out in ICU professionals

Professional burnout has been described by WHO as a syndrome conceptualised as resulting from chronic workplace stress that has not been successfully managed. Intensive care unit (ICU) professionals a...

15 Mai 202413min

Inflammatory subphenotypes in patients at risk of ARDS: evidence from the LIPS-A trial

Inflammatory subphenotypes in patients at risk of ARDS: evidence from the LIPS-A trial

Acute respiratory distress syndrome (ARDS) remains a life-threatening syndrome, resulting in high morbidity and mortality. In ARDS patients and mechanically ventilated critically ill patients, two dis...

8 Mai 202421min

Brain ultrasound for the general intensivist

Brain ultrasound for the general intensivist

Cerebral ultrasound is a developing point-of-care tool for intensivists and emergency physicians, with an important role in diagnosing acute intracranial pathology. The use of transcranial Doppler has...

24 Apr 202416min

Phenotyping and endotyping patients to optimally set nutrition targets

Phenotyping and endotyping patients to optimally set nutrition targets

Nutrition plays a vital role in the management of critically ill patients, and a tailored approach based on patient assessment, nutritional requirements, and clinical status is essential for optimisin...

10 Apr 202447min

Populært innen Business og økonomi

stopp-verden
dine-penger-pengeradet
e24-podden
rss-penger-polser-og-politikk
rss-borsmorgen-okonominyhetene
lydartikler-fra-aftenposten
pengepodden-2
utbytte
finansredaksjonen
pengesnakk
livet-pa-veien-med-jan-erik-larssen
morgenkaffen-med-finansavisen
okonomiamatorene
tid-er-penger-en-podcast-med-peter-warren
rss-sunn-okonomi
stormkast-med-valebrokk-stordalen
lederpodden
rss-fa-makro
rss-markedspuls-2
boligbobla