Nature Podcast4 Des 2024

Why breast cancer treatments might work best just after your period

00:48 Chemotherapy efficacy varies with the menstrual cycle

Breast cancer cells are more susceptible to chemotherapy at certain points in the menstrual cycle, new data in Nature suggests. Researchers studied the equivalent hormonal cycle in mice and found that during the oestrous phase, where progesterone levels are low, tumours are more susceptible to chemotherapy. The same effect was shown in humans in a small retrospective study. The team caution that a larger clinical trial would need to be conducted, but hope that this work could open up an, easy to implement, way to boost the effect of chemotherapy.

Research Article: Bornes et al.

News and Views: What is the best time of the month to treat breast cancer?

09:22 Research Highlights

How coffee changes your gut microbiota, and the first amber deposits found in Antarctica hint at an ancient rainforest.

Research Highlight: Do you drink coffee? Ask your gut

Research Highlight: Antarctica’s first known amber whispers of a vanished rainforest

11:47 Is human-level artificial intelligence close?

The latest AI system released by OpenAI, the makers of ChatGPT, is better able to break down problems into smaller chunks, making it closer to a human way of solving problems than other systems. This has reignited discussions about the likelihood of AIs achieving human-level intelligence. Although previously the realm of science fiction, researchers are now taking the idea of ‘artificial general intelligence’, or AGI, more seriously. Although this technology has the potential to help tackle humanity's biggest challenges, there are concerns about the safety of such technology if it were to become autonomous.

News Feature: How close is AI to human-level intelligence?

21:43 Briefing Chat

How making a bank of centenarians’ stem cells could help unlock the secrets of healthy ageing, and what some 1.5 million year old footprints reveal about how ancient hominin species may have interacted.

Nature: What’s the secret to living to 100? Centenarian stem cells could offer clues

Nature: These two ancient human relatives crossed paths 1.5 million years ago

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Episoder(924)

Briefing Chat: How 1,000 pairs of buried underpants helped measure soil health

In this episode:00:21 Our picks of this year’s Ig Nobel prizesNature: Buried underpants and a new definition of kissing win 2026 Ig Nobel prizes07:47 Massive xenon experiment detects tantalizing hint ...

4 Sep 12min

Audio long read: Could mending damaged DNA prolong life?

Scientists are amassing evidence that unrepaired or poorly repaired DNA damage underlies many of the hallmarks of ageing. This has led to research into whether boosting DNA repair can keep people heal...

2 Sep 18min

Briefing Chat: How Dolly Parton left her mark on science

In this episode:00:18 Researchers celebrate Dolly Parton's contributions to scienceNature: Dolly Parton dies aged 80 — researchers celebrate her contributions to science08:40 Phase III trial of melano...

28 Aug 14min

Highest-ever ocean temperatures recorded as El Niño intensifies

Why extreme temperatures are expected to weaken ocean carbon sinks — plus, how mitochondrial injections could treat vision loss.00:46 The world’s oceans reach a record temperatureNature: Ocean tempera...

26 Aug 19min

Briefing Chat: New narcolepsy drug could unlock host of novel brain therapies

Nature staff discuss how an FDA-approved drug for narcolepsy could have promise beyond the condition, and the longest-lived human brain organoids yet.00:28 The promise of a new narcolepsy drugNature: ...

21 Aug 12min

A black hole's spin could finally be measured by a high-speed star

Star orbiting close to Sagittarius A* could reveal its spin — plus, how exoskeletons might change the way humans move.00:46 The star that could reveal a black hole’s spinResearch article: Dayem et al....

19 Aug 29min

Briefing Chat: Anthropic rolls out new AI watermark — will it make a difference?

In this episode:00:29 What does Anthropic’s new watermark mean for research?Nature: Can Anthropic’s invisible watermarks curb ‘AI slop’? Researchers remain sceptical10:57 Ticklishness is a distinct, s...

14 Aug 16min

The probiotic bacteria engineered to treat diabetes

Genetically modified bacteria lower high blood-sugar in animal trials — plus, how to safely watch a solar eclipse.00:45 A living diabetes treatmentResearch article: Guan et al.08:03 Research Highlight...

12 Aug 19min