298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

Episoder(415)

AMA | May 2023

AMA | May 2023

Welcome to the May 2023 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreon...

8 Mai 20233h 8min

235 | Andy Clark on the Extended and Predictive Mind

235 | Andy Clark on the Extended and Predictive Mind

What is the mind, and what does it try to do? An overly simplified materialist view might be that the mind emerges from physical processes in the brain. But you can be a materialist and still recogniz...

1 Mai 20231h 21min

234 | Tobias Warnecke on Cellular Structure and Evolution

234 | Tobias Warnecke on Cellular Structure and Evolution

Eukaryotic cells manage to pull off a number of remarkable feats. One is packing quite a long DNA molecule, with potentially billions of base pairs, into a tiny central nucleus. A key role is played b...

24 Apr 20231h 6min

233 | Hugo Mercier on Reasoning and Skepticism

233 | Hugo Mercier on Reasoning and Skepticism

Here at the Mindscape Podcast, we are firmly pro-reason. But what does that mean, fundamentally and in practice? How did humanity come into the idea of not just doing things, but doing things for reas...

17 Apr 20231h 12min

232 | Amy Finkelstein on Adverse Selection and Hidden Information

232 | Amy Finkelstein on Adverse Selection and Hidden Information

If you knew exactly when every person was going to die, or require medical care, you could make a killing buying and selling insurance. Nobody knows these things, of course -- the future is hard to pr...

10 Apr 20231h 13min

Ask Me Anything | April 2023

Ask Me Anything | April 2023

Welcome to the April 2023 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patre...

3 Apr 20234h 4min

231 | Sarah Bakewell on the History of Humanism

231 | Sarah Bakewell on the History of Humanism

Human beings are small compared to the universe, but we're very important to ourselves. Humanism can be thought of as the idea that human beings are themselves the source of meaningfulness and matteri...

27 Mar 20231h 21min

230 | Raphaël Millière on How Artificial Intelligence Thinks

230 | Raphaël Millière on How Artificial Intelligence Thinks

Welcome to another episode of Sean Carroll's Mindscape. Today, we're joined by Raphaël Millière, a philosopher and cognitive scientist at Columbia University. We'll be exploring the fascinating topic ...

20 Mar 20231h 57min

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