298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

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Episoder(426)

AMA | June 2025

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Welcome to the June 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreo...

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316 | Niayesh Afshordi and Phil Halper

316 | Niayesh Afshordi and Phil Halper

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315 | Branden Fitelson on the Logic and Use of Probability

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314 | Karen Lloyd on the Deep Underground Biosphere

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313 | Eric Topol on the Changing Face of Medicine and Aging

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AMA | May 2025

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Welcome to the May 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreon...

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312 | Thomas Levenson on the Mutual History of Humans and Germs

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311 | Annaka Harris on Whether Consciousness is Fundamental

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Questions about consciousness range from the precise and empirical -- what neurons fire when I have some particular experience -- to the deeply profound -- does consciousness emerge from matter, or do...

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