Benzodiazepine EXPERT Reveals Liver Metabolism Secrets

Benzodiazepine EXPERT Reveals Liver Metabolism Secrets

Discover the fascinating world of benzodiazepines as we break down their metabolism, kinetics, and clinical impact. In this episode, we explore how the liver processes these commonly prescribed medications, highlighting the critical role of the cytochrome P4503A4 system. Learn why some benzodiazepines bypass phase 1 oxidation and how this affects their safety in elderly patients or those with liver disease. We also dive into the science of drug interactions, detailing how inhibitors and inducers of the SIP 3A4 enzyme can significantly alter plasma concentrations of benzodiazepines like diazepam. Plus, find out why tolerance develops, including uncoupling, receptor internalisation, and receptor insensitivity at the GABAA site. Whether you're a clinician or curious learner, this video equips you with essential knowledge on selecting the right benzodiazepine for specific conditions like anxiety, insomnia, or epilepsy. Don’t miss our insights into the dangers of long-term use and the development of tolerance.

Episoder(238)

Dopamine, Relapse, and Recovery: Why Addiction Needs Long-Term Management

Dopamine, Relapse, and Recovery: Why Addiction Needs Long-Term Management

A lot of people still think addiction recovery is just about willpower.But addiction neuroscience tells a different story: dopamine, the reward system, and relapse risk all help explain why recovery o...

25 Mar 5min

Why You Can Be Detoxed and Still Addicted

Why You Can Be Detoxed and Still Addicted

Addiction neuroscience, dopamine, cravings: detox ends withdrawal, but it does not end addiction.The MythA common myth in addiction recovery is that once detox is over, the problem is solved. Many peo...

18 Mar 5min

Relapse Happens to Everyone: Here's the Science Why - Addiction Basics 06

Relapse Happens to Everyone: Here's the Science Why - Addiction Basics 06

Dr. Fergal Armstrong reframes relapse in addiction, explaining why it's not a personal failure but a common part of the recovery journey, comparable to chronic illnesses. Understanding the neuroscienc...

11 Mar 5min

The Science of Withdrawal: What's Actually Happening? - Addiction Basics #5

The Science of Withdrawal: What's Actually Happening? - Addiction Basics #5

Withdrawal is one of the most feared parts of addiction recovery.But neuroscience shows something important:Withdrawal isn’t a failure of willpower — it’s the brain restoring balance after long-term c...

4 Mar 5min

Addiction vs Dependence vs Tolerance: The Critical Medical Difference

Addiction vs Dependence vs Tolerance: The Critical Medical Difference

🚨 TOLERANCE ≠ ADDICTION 🚨Most people — even healthcare professionals — use these terms incorrectly.And that confusion is hurting patients.In this episode, we break down:🧠 The real definition of add...

25 Feb 5min

Why Buprenorphine Is Safer Than Full Opioid Agonists

Why Buprenorphine Is Safer Than Full Opioid Agonists

Most people think methadone is the only real option for opioid addiction.Wrong.Buprenorphine — especially long-acting injectable depot — is flipping the entire system upside down.No daily pharmacy vis...

23 Feb 28min

How Cravings Work: Limbic System vs Prefrontal Cortex - Addiction Basics EP3

How Cravings Work: Limbic System vs Prefrontal Cortex - Addiction Basics EP3

Addiction neuroscience explains why wanting to quit isn’t the same as being able to quit. Dopamine reshapes the brain’s reward system.In Episode 3 of Addiction Basics, we tackle one of the most painfu...

18 Feb 6min

Dopamine and Addiction: The Science of Cravings - Addiction Basics EP2

Dopamine and Addiction: The Science of Cravings - Addiction Basics EP2

Addiction neuroscience explained. Dopamine, cravings, brain recovery, and neuroplasticity — backed by research.If you’ve ever wondered how addiction works in the brain, this is the science most people...

12 Feb 6min

Populært innen Helse

lydartikler-fra-aftenposten
fastlegen
hvordan-har-du-det-mann
rss-gukild-johaug
psykodrama
relasjonspodden-med-dora-thorhallsdottir-kjersti-idem
rss-garne-damer
leger-om-livet
foreldreradet
bak-fasaden-en-reise-i-livet-med-sykepleier-ine
morten-ramm-lar-kakla-ga-til-du-sovner
rss-lopedrommen
hormonelle-frida
klimaks
sinnsyn
g-punktet
rss-sunn-okonomi
hjernesterk
helsetipspodden
hverdagspsyken