Benzodiazepine EXPERT Reveals Liver Metabolism Secrets

Benzodiazepine EXPERT Reveals Liver Metabolism Secrets

Discover the fascinating world of benzodiazepines as we break down their metabolism, kinetics, and clinical impact. In this episode, we explore how the liver processes these commonly prescribed medications, highlighting the critical role of the cytochrome P4503A4 system. Learn why some benzodiazepines bypass phase 1 oxidation and how this affects their safety in elderly patients or those with liver disease. We also dive into the science of drug interactions, detailing how inhibitors and inducers of the SIP 3A4 enzyme can significantly alter plasma concentrations of benzodiazepines like diazepam. Plus, find out why tolerance develops, including uncoupling, receptor internalisation, and receptor insensitivity at the GABAA site. Whether you're a clinician or curious learner, this video equips you with essential knowledge on selecting the right benzodiazepine for specific conditions like anxiety, insomnia, or epilepsy. Don’t miss our insights into the dangers of long-term use and the development of tolerance.

Episoder(238)

Asthma, COPD, Emphysema: The Smoking Connection Explained

Asthma, COPD, Emphysema: The Smoking Connection Explained

Every puff of cigarette smoke delivers toxic chemicals deep into your lungs—triggering a cascade of damage that most people don’t realise until it’s too late. Dr. Ferghal Armstrong dives into the deva...

18 Sep 202532s

Smoking’s Secret Weapon: Vascular Poison in Every Puff

Smoking’s Secret Weapon: Vascular Poison in Every Puff

Smoking’s Secret Weapon: Vascular Poison in Every PuffIn this high-voltage episode of Cracking Addiction, Dr  Ferghal Armstrong delivers a powerful reminder: cardiovascular disease is the most immedia...

11 Sep 20257min

The Shocking Truth About Smoking and Cancer!

The Shocking Truth About Smoking and Cancer!

The Shocking Truth About Smoking and Cancer!Part 3This video dives deep into the molecular chaos caused by tobacco smoke, revealing how it doesn’t just increase cancer risk—it drives it. Every puff de...

4 Sep 20256min

Cigarettes Today Are Engineered for Addiction — Here's How - Part 1 of 6

Cigarettes Today Are Engineered for Addiction — Here's How - Part 1 of 6

Cigarettes Today Are Engineered for Addiction — Here's How.PART 1 of 6 "Unfiltered: Inside the Smoke"Today’s cigarettes are a far cry from the simple tobacco rolls of the past. In this explosive episo...

1 Sep 20256min

Shocking Facts About Cigarette Chemicals!

Shocking Facts About Cigarette Chemicals!

Shocking Facts About Cigarette Chemicals!Cigarettes are more than just dried tobacco—they’re chemical weapons in disguise. In this eye-opening episode of Cracking Addiction, Dr. Ferghal Armstrong dive...

27 Aug 20256min

How to Stop Shopping Addiction Signs, Diagnosis & Real-Life Impact

How to Stop Shopping Addiction Signs, Diagnosis & Real-Life Impact

How to Stop Shopping Addiction Signs, Diagnosis & Real-Life ImpactIs. Is It Just Retail Therapy — or Something Deeper?Is your shopping habit harmless fun, or could it be compulsive buying disorder (on...

14 Aug 20256min

Dr Amstrong Shares Ways to Help With Porn Addiction!

Dr Amstrong Shares Ways to Help With Porn Addiction!

Dr Armstrong Shares Ways to Help With Porn Addiction!Are you battling porn addiction symptoms or wondering why porn addiction is harmful? In this eye-opening episode of Cracking Addiction, Dr. Ferghal...

31 Jul 20256min

Is Porn Addiction Real? | Truth Behind Porn Addiction Explained

Is Porn Addiction Real? | Truth Behind Porn Addiction Explained

Is Porn Addiction Real? | Truth Behind Porn Addiction ExplainedIs porn addiction actually real — or just a myth? In this eye-opening episode of Cracking Addiction, Dr. Ferghal Armstrong explores what ...

23 Jul 20257min

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