Episode 392: 403. 3 Papers, 1 Podcast - One Guideline Changer
https://jamanetwork.com/journals/jama/article-abstract/2834040amiloride is realistically equal to spironolactone for resistant HTNhttps://journals.lww.com/ajg/abstract/2025/05000/higher_rate_of_sponta...
16 Jun 202514min
Episode 391: 402. Functional disability after clinically significant extracranial bleeding: a secondary analysis of ASPREE
https://www.jthjournal.org/article/S1538-7836(25)00109-6/fulltextAntithrombotic agents, like aspirin and anticoagulants, are essential for treating many cardiovascular conditions. However, a common si...
5 Jun 20257min
Episode 390: 401. Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension
https://jamanetwork.com/journals/jama/article-abstract/2834632SummaryThe article examines the effectiveness and safety of zilebesiran, an RNA interference therapeutic agent, when used in combination w...
4 Jun 20258min
Episode 389: 400. CRP, Lipoprotein A, LDL for cardiac risk assessment
https://www.nejm.org/doi/full/10.1056/NEJMoa2405182?query=recirc_Semantic Key Takeaways Extended Predictive Value of Biomarkers: High-sensitivity C-reactive protein (CRP), LDL cholesterol, and lipop...
29 Mai 20259min
Episode 388: 399. Use of albumin-adjusted calcium measurements in clinical practice
Desgagnés N et al. Use of albumin-adjusted calcium measurements in clinical practice. JAMA Netw Open 2025 Jan 21; 8:e2455251. (https://doi.org/10.1001/jamanetworkopen.2024.55251)Overall, total calcium...
27 Mai 20257min
Episode 387: 398. Which is Better, Tirzepatide or Semaglutide?
https://www.nejm.org/doi/10.1056/NEJMoa2416394At 72 weeks, the mean percentage decrease in weight was significantly greater with tirzepatide than with semaglutide (20% vs. 14%). Gastrointestinal side ...
21 Mai 20258min
Episode 386: 397. What is the new drug for smoking cessation?
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2832701In this multisite trial, 800 adults who smoked 10 or more cigarettes daily (mean duration of smoking, ≈35 years) were randomize...
9 Mai 20255min
Episode 385: 396. Vitamin D and Kids (CME)
What does the evidence and the guidelines say about the use and testing of Vitamin D in kids
7 Mai 20258min
