Episode 171: 171.  Diabetes Drugs, Statins and Muscle Pain, Vitamin D and COVID, Acne and Food

Episode 171: 171. Diabetes Drugs, Statins and Muscle Pain, Vitamin D and COVID, Acne and Food

SGLT2 inhibitors and GLP1 agonists administered without metformin compared to other glucose‐lowering drugs in patients with type 2 diabetes mellitus to prevent cardiovascular events: A systematic review - Escobar - 2021 - Diabetic Medicine - Wiley Online Library

Yes these fancy new drugs work with and without metformin but that does not mean these drugs should be first line!!


Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial | Complementary and Alternative Medicine | JAMA | JAMA Network


Yep even 200,000IU of vit D does nothing except raise your vit d level.

Diet and acne: review of the evidence from 2009 to 2020 - Dall’Oglio - - International Journal of Dermatology - Wiley Online Library


What you eat does mess with your acne, or at least says this large observational trial.


Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials | The BMJ

The muscle aches with statins is a common event that it occurs as frequently with the active drug as it does with placebo

Episoder(385)

Episode 334: 333. Cell Phone Use While Driving and Financial Gain

Episode 334: 333. Cell Phone Use While Driving and Financial Gain

Feedback and Financial Incentives for Reducing Cell Phone Use While Driving: A Randomized Clinical Trial | Public Health | JAMA Network Open | JAMA Network  Question  Can behavioral interventions decr...

2 Okt 20248min

Episode 333: 331. Noncontrast CT Selected Thrombectomy vs Medical Management

Episode 333: 331. Noncontrast CT Selected Thrombectomy vs Medical Management

Noncontrast CT Selected Thrombectomy vs Medical Management for Late-Window Anterior Large Vessel Occlusion | Neurology Most studies that have shown a benefit from endovascular thrombectomy (EVT) for i...

24 Sep 20246min

Episode 332: 330. Does a Multivitamine a Day Keep The Death Away?

Episode 332: 330. Does a Multivitamine a Day Keep The Death Away?

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820369With as many as 1 in 3 US adults using multivitamin supplements, the question as to whether these supplements reduce mortality They ...

18 Sep 20246min

Episode 331: 329. Should We Give AceI or ARBs to Patients with CKD 4 and 5?

Episode 331: 329. Should We Give AceI or ARBs to Patients with CKD 4 and 5?

https://www.acpjournals.org/doi/10.7326/M23-3236Angiotensin-converting–enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs) seldom are initiated among patients with chronic kidney disease (...

17 Sep 20247min

Episode 330: 328. Methods Monday, Composite Endpoints

Episode 330: 328. Methods Monday, Composite Endpoints

Composite outcomes You add multiple outcomes together… this is great because you can increase the event rate.. if you are just looking at death lots of people might now die but if you look at death an...

16 Sep 202411min

Episode 329: 327. A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening "SHIELD TESTING"

Episode 329: 327. A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening "SHIELD TESTING"

ening, the offer of a blood-based screening test boosted CRC screening by 17.5 percentage points over usual care.That is becauseCRC screening proportions were 17.5 percentage points higher in the bloo...

23 Aug 202412min

Episode 328: 327. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk

Episode 328: 327. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk

https://pubmed.ncbi.nlm.nih.gov/38945140/The primary outcome was a composite of myocardial infarction, revascularisation, hospitalisation for heart failure, stroke, or death from cardiovascular causes...

2 Aug 20247min

Episode 327: 326. Should We Prescribe Inhaled Insulin? INHALE-3 TRIAL

Episode 327: 326. Should We Prescribe Inhaled Insulin? INHALE-3 TRIAL

INHALE-3, a randomized trial, 123patients with type 1 dm that compared the efficacy of an inhaled insulin regimen (Afrezza) plus degludec insulin (Tresiba®) against usual care over 17 weeks The study'...

1 Aug 20247min

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