Episode 320: 319. President Biden has COVID, Should the First Lady Take Paxlovid?
https://www.nejm.org/doi/full/10.1056/NEJMoa2309002In this placebo-controlled trial, postexposure prophylaxis with nirmatrelvir–ritonavir for 5 or 10 days did not significantly reduce the risk of symp...
18 Jul 20248min
Episode 319: 318. Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide
Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutidethis paper out in JAMA makes you think this is an issue but likely just too much noise with only 17 patietns a...
17 Jul 20249min
Episode 318: 317. METHODS MONDAY- What is a Confounder?
Be careful, most observational data have a large amount of confounders not accounted for and even when accounted for you can never account for all the confounders
15 Jul 202410min
Episode 317: 316. Guideline for the Management of Lower Extremity Peripheral Artery Disease
https://www.ahajournals.org/doi/10.1161/CIR.0000000000001251. Diagnosis:To establish a PAD diagnosis, the resting ankle–brachial index (ABI) remains the initial test of choice in patients with suggest...
10 Jul 20245min
Episode 316: 315. Prognostic Value of Cardiovascular Biomarkers in the Population
https://jamanetwork.com/journals/jama/article-abstract/2818624Conclusion--“Cardiovascular biomarkers were strongly associated with fatal and nonfatal cardiovascular events and mortality. The addition ...
9 Jul 20246min
Episode 315: 314. METHODS MONDAY! What Is A C-Score?
What are c statisticsC-statistic gives the probability a randomly selected patient who experienced an event (e.g. a disease or condition) had a higher risk score than a patient who had not experienced...
8 Jul 20247min
Episode 314: 313. Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19
https://pubmed.ncbi.nlm.nih.gov/38598573/In fully vaccinated adults with a risk factor or unvaccinated patients without a risk factor who have symptomatic COVID-19, does paxlovid--nirmatrelvir-ritonav...
5 Jul 20245min
Episode 313: 312. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size
https://www.nejm.org/doi/10.1056/NEJMoa2314063Randomized trials have shown the benefit of endovascular thrombectomy in patients with acute stroke due to large-artery occlusion in the anterior circulat...
3 Jul 20247min
