Episode 272: 271. Cologaurd Has a New Test? How Good is it?
The company that developed Cologuard also developed this “next generation” multitarget stool DNA test, and has applied for U.S. FDA approval. The new test appears to have similar sensitivity and highe...
17 Apr 20245min
Episode 271: 270. Aprocitentan, How Well Does it Work for Resistant Hypertension?
730 Patients were randomized to receive daily oral aprocitentan or placebo, plus a fixed-dose combination of amlodipine, valsartan, and hydrochlorothiazide.After 4 weeks, mean change in office systoli...
16 Apr 20246min
Episode 270: 269. What is the Harm in Aspirin?
The trial was terminated after 1015 patients with atrial cardiopathy had been randomized to receive either apixaban or aspirin for a mean follow-up of 1.8 years, recurrent stroke rates were identical...
15 Apr 20244min
Episode 268: 268. New Guidelines For Total Hip and Knee Joint Replacement
TJA should not be delayed for trials of physical therapy, anti-inflammatory drug use, bracing, intra-articular steroid injections, or hyaluronic acid injections. For patients with obesity, proceed to...
12 Apr 20247min
Episode 269: 267. Beta Blockers DON'T Help Post-MI
randomized trial comparingbeta-blocker therapy (metoprolol or bisoprolol) with no beta-blocker in 5020 patients who had a normal left-ventricular ejection fraction (LVEF) after AMI median follow-up of...
11 Apr 20246min
Episode 267: 266. How Many Years Of Smoking Cessation Do You Need?
During a mean 11 years of follow-up, current smokers' risks for cardiovascular-, cancer-, and respiratory-related deaths were 2, 3, and 13 times higher, respectively, than never smokers' risks. Former...
10 Apr 20245min
Episode 266: 265. Semaglutide and Cardiovascular Events in Non-Diabetics (secondary prevention) SELECT TRIAL
The primary cardiovascular end point was a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke in a time-to-first-event analysis.Improvement innonfatal st...
9 Apr 20248min
Episode 265: 264. Does a Lidocaine Patch Work for Neck Pain?
Bottom line(ZTLido 1.8%) is a brand name lidocaine patch currently approced for postherpetic neuralgia and will stay that why for now as it did not beat placebo for the treatment of patients with chro...
5 Apr 20245min
