Episode 393: 404. 3 quick articles you might want to know about (oral semaglutide, tiktok, and GLP1 thyroid cancer)
GLP1 might cause thyroid cancer in mice but the evidence is drastically lacking in humansOral semaglutide is expensive for an NNT of 50 at 4 yrsTiktok videos of skin care are a scam
25 Jun 202512min
Episode 392: 403. 3 Papers, 1 Podcast - One Guideline Changer
https://jamanetwork.com/journals/jama/article-abstract/2834040amiloride is realistically equal to spironolactone for resistant HTNhttps://journals.lww.com/ajg/abstract/2025/05000/higher_rate_of_sponta...
16 Jun 202514min
Episode 391: 402. Functional disability after clinically significant extracranial bleeding: a secondary analysis of ASPREE
https://www.jthjournal.org/article/S1538-7836(25)00109-6/fulltextAntithrombotic agents, like aspirin and anticoagulants, are essential for treating many cardiovascular conditions. However, a common si...
5 Jun 20257min
Episode 390: 401. Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension
https://jamanetwork.com/journals/jama/article-abstract/2834632SummaryThe article examines the effectiveness and safety of zilebesiran, an RNA interference therapeutic agent, when used in combination w...
4 Jun 20258min
Episode 389: 400. CRP, Lipoprotein A, LDL for cardiac risk assessment
https://www.nejm.org/doi/full/10.1056/NEJMoa2405182?query=recirc_Semantic Key Takeaways Extended Predictive Value of Biomarkers: High-sensitivity C-reactive protein (CRP), LDL cholesterol, and lipop...
29 Mai 20259min
Episode 388: 399. Use of albumin-adjusted calcium measurements in clinical practice
Desgagnés N et al. Use of albumin-adjusted calcium measurements in clinical practice. JAMA Netw Open 2025 Jan 21; 8:e2455251. (https://doi.org/10.1001/jamanetworkopen.2024.55251)Overall, total calcium...
27 Mai 20257min
Episode 387: 398. Which is Better, Tirzepatide or Semaglutide?
https://www.nejm.org/doi/10.1056/NEJMoa2416394At 72 weeks, the mean percentage decrease in weight was significantly greater with tirzepatide than with semaglutide (20% vs. 14%). Gastrointestinal side ...
21 Mai 20258min
Episode 386: 397. What is the new drug for smoking cessation?
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2832701In this multisite trial, 800 adults who smoked 10 or more cigarettes daily (mean duration of smoking, ≈35 years) were randomize...
9 Mai 20255min
