Episode 271: 270. Aprocitentan, How Well Does it Work for Resistant Hypertension?

Episode 271: 270. Aprocitentan, How Well Does it Work for Resistant Hypertension?

730 Patients were randomized to receive daily oral aprocitentan or placebo, plus a fixed-dose combination of amlodipine, valsartan, and hydrochlorothiazide.
After 4 weeks, mean change in office systolic BP was 15 mm Hg with aprocitentan and 11 mm Hg with placebo; this 4 mm difference was statistically significant.
What is the cost? What is the long term effects? Why didn't they compare this to the standard of care spironolactone?

https://www.hcplive.com/view/fda-approves-aprocitentan-tryvio-for-treatment-resistant-hypertension

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02034-7/abstract

Episoder(386)

67. HPV, BPH, CTA and I'm ACB

67. HPV, BPH, CTA and I'm ACB

Yes! I am Andrew Christopher Buelt and in this all abbreviation and intial podcast I break down some recent studies that might are of interst. First, is HPV testing alone good enough? Should you do a ...

3 Apr 201820min

66. Zika, Concussion, Hip Surgery, New Guidelines

66. Zika, Concussion, Hip Surgery, New Guidelines

Is Zika as scary as we really think, or is it scarier?! There is a new test for concussion, right? You might wait a day for a hip surgery but don't wait two! Finally, This podcast is sweet but the new...

21 Mar 201819min

65. A Poor Prognosis of PE, UTI, Smoking

65. A Poor Prognosis of PE, UTI, Smoking

Andrew covers four articles that give a POOR PHYSICIAN PROGNOSIS for the rates of PE, the push for no-antibiotic-UTI, and smoking.

10 Mar 201819min

61. Joe Is Back To Discuss Three Articles

61. Joe Is Back To Discuss Three Articles

Guess who is back?! Joe joins me on QM and we talk about three recent trials give our thoughts and opinions while we both sip on a Diet Dr. Pepper. It is a quick 20 minutes of us talking out what we a...

4 Feb 201821min

60. New Format for Questioning Medicine

60. New Format for Questioning Medicine

Turns out when people say, 'You couldn't pay me enough money to quit smoking!' What they meant was "Can you please give me $750?" Kay-x still isn't great. I give my two cents on the hypertension guide...

1 Feb 201823min

59. DNR Listening to What You Should Watch

59. DNR Listening to What You Should Watch

How good are you at the DNR conversation? It is a conversation we all need to have with our patients no matter the field or specialty of medicine. However, it's a conversation we all avoid like the pl...

8 Des 201713min

58. Who pays when they leave AMA?

58. Who pays when they leave AMA?

Does insurance pay? Does the patient pay? What do you think? What do most Doctors think? Is it possible for me to write this entire description in only question form?

1 Des 20178min

57. Triple Therapy for AFIB After PCI, Trick or Treat?

57. Triple Therapy for AFIB After PCI, Trick or Treat?

We need to thin out the blood. Afib then to PCI and boom triple therapy. However, I suspect times are changing. It is Halloween and I do my best to play future fortune teller and predict the future in...

1 Nov 201725min

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