Episode 301: 300. A New Trial On Beta Blockers and COPD

Episode 301: 300. A New Trial On Beta Blockers and COPD

The problems with observation data is real—

randomized trial, U.K. researchers identified 519 patients (mean age, 68) with mostly moderate COPD (mean forced expiratory volume in 1 second [FEV1], 50%), ≥2 exacerbations during the previous year, and no cardiovascular (CV) indications for β-blockers.

Patients were randomized to receive the cardioselective β-blocker bisoprolol (initially 1.25 mg daily, titrated to 5 mg if tolerated) or placebo.

At 1 year, no significant differences were noted between groups in incidence of COPD exacerbations or in other important benefits or harms.



Cardioselective β-blockers remain appropriate for COPD patients who have valid cardiovascular indications for their use, but taken these two studies together suggests that COPD patients without such indications should avoid bblockers—even cardio selective beta blockers

https://jamanetwork.com/journals/jama/article-abstract/2819083

Episoder(386)

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75. Sun Protection, Prostate and Atrial Fib Screening?

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74. Lots of articles and 2 that will change guidelines

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73. Compressing evidence on bones, colon cancer, pregnancy loss and listen questions

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72. Swelling Over ACEI and Seizing On 3 Articles

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27 Jun 201828min

71. Breaking Bones and A1C Levels Should Put You into A.fib

71. Breaking Bones and A1C Levels Should Put You into A.fib

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70. More Articles and a Vegan Study To Make a T-Rex Eat a Salad

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 69. NBA playoffs w/ Coronary Calcium, VEST, and Dialysis O, MY

69. NBA playoffs w/ Coronary Calcium, VEST, and Dialysis O, MY

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68. Anti-biotics Still Have Harm and 2 Guidelines to Know About

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