Episode 304: 303. Associations Between Surrogate Markers and Clinical Outcomes

Episode 304: 303. Associations Between Surrogate Markers and Clinical Outcomes


Question What is the strength of association between surrogate markers used as primary end points in clinical trials to support Food and Drug Administration (FDA) approval of drugs treating nononcologic chronic diseases and clinical outcomes?

often surrogate markers are used as primary end points in clinical trials to support FDA approval of drugs

I get it

Surrogate markers offer the advantage of reducing the duration, size, and total cost of trials

n 2018, the Food and Drug Administration (FDA) publicly released an Adult Surrogate Endpoint Table of more than 100 surrogate markers that may be used as primary end points in clinical trials that form the basis of traditional or accelerated approval of new drugs or biologics.

The authors evaluated Thirty-seven surrogate markers listed in FDA’s table of markers that can be used as primary end points in clinical trials across 32 unique nononcologic chronic diseases.


Most surrogate markers used as primary end points in clinical trials to support FDA approval of drugs treating nononcologic chronic diseases lacked high-strength evidence of associations with clinical outcomes from published meta-analyses.


https://jamanetwork.com/journals/jama/article-abstract/2817850

Episoder(386)

67. HPV, BPH, CTA and I'm ACB

67. HPV, BPH, CTA and I'm ACB

Yes! I am Andrew Christopher Buelt and in this all abbreviation and intial podcast I break down some recent studies that might are of interst. First, is HPV testing alone good enough? Should you do a ...

3 Apr 201820min

66. Zika, Concussion, Hip Surgery, New Guidelines

66. Zika, Concussion, Hip Surgery, New Guidelines

Is Zika as scary as we really think, or is it scarier?! There is a new test for concussion, right? You might wait a day for a hip surgery but don't wait two! Finally, This podcast is sweet but the new...

21 Mar 201819min

65. A Poor Prognosis of PE, UTI, Smoking

65. A Poor Prognosis of PE, UTI, Smoking

Andrew covers four articles that give a POOR PHYSICIAN PROGNOSIS for the rates of PE, the push for no-antibiotic-UTI, and smoking.

10 Mar 201819min

61. Joe Is Back To Discuss Three Articles

61. Joe Is Back To Discuss Three Articles

Guess who is back?! Joe joins me on QM and we talk about three recent trials give our thoughts and opinions while we both sip on a Diet Dr. Pepper. It is a quick 20 minutes of us talking out what we a...

4 Feb 201821min

60. New Format for Questioning Medicine

60. New Format for Questioning Medicine

Turns out when people say, 'You couldn't pay me enough money to quit smoking!' What they meant was "Can you please give me $750?" Kay-x still isn't great. I give my two cents on the hypertension guide...

1 Feb 201823min

59. DNR Listening to What You Should Watch

59. DNR Listening to What You Should Watch

How good are you at the DNR conversation? It is a conversation we all need to have with our patients no matter the field or specialty of medicine. However, it's a conversation we all avoid like the pl...

8 Des 201713min

58. Who pays when they leave AMA?

58. Who pays when they leave AMA?

Does insurance pay? Does the patient pay? What do you think? What do most Doctors think? Is it possible for me to write this entire description in only question form?

1 Des 20178min

57. Triple Therapy for AFIB After PCI, Trick or Treat?

57. Triple Therapy for AFIB After PCI, Trick or Treat?

We need to thin out the blood. Afib then to PCI and boom triple therapy. However, I suspect times are changing. It is Halloween and I do my best to play future fortune teller and predict the future in...

1 Nov 201725min

Populært innen Helse

fastlegen
lydartikler-fra-aftenposten
rss-gukild-johaug
hvordan-har-du-det-mann
psykodrama
leger-om-livet
relasjonspodden-med-dora-thorhallsdottir-kjersti-idem
rss-garne-damer
hormonelle-frida
foreldreradet
morten-ramm-lar-kakla-ga-til-du-sovner
hjernesterk
bak-fasaden-en-reise-i-livet-med-sykepleier-ine
rss-lopedrommen
klimaks
g-punktet
rss-kunsten-a-leve
treningsprat
rss-kull
helsetipspodden