Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Episoder(385)

Episode 246: 246. In Giant Cell Arteritis How Soon Do You Need To Get A Biopsy After Starting Steroids?

Episode 246: 246. In Giant Cell Arteritis How Soon Do You Need To Get A Biopsy After Starting Steroids?

Just get he biopsy at less than 6 weeks after starting therapy as the yield was the same at 2 weeks as it was at 4-6 weekshttps://pubmed.ncbi.nlm.nih.gov/36642440/

23 Feb 20244min

Episode 245: 245. Do Baby Walkers Cause Developmental Delays?

Episode 245: 245. Do Baby Walkers Cause Developmental Delays?

Evidence against baby walker is not enough regarding its negative effect on child development. This subject needs to be addressed more, considering a large number of baby walker users worldwide.https:...

22 Feb 202420min

Episode 244: 244. Does Testosterone CAUSE Prostate Cancer?

Episode 244: 244. Does Testosterone CAUSE Prostate Cancer?

During average follow-up of in this study the incidence of prostate cancer was less than 1% — and not significantly different  Remember most of these pts had testosterone levels around 350 ish give or...

20 Feb 20244min

Episode 243: 243. Can Testosterone Improve or Treat Depression?

Episode 243: 243. Can Testosterone Improve or Treat Depression?

From a mean score of 45 points at baseline, mood improved by about 5 points in the placebo group and 6 points in the testosterone group — a statistically significant but small difference. I think you ...

19 Feb 20246min

Episode 242: 242. Does Testosterone Improve Sexual Function and Erectile Dysfunction?

Episode 242: 242. Does Testosterone Improve Sexual Function and Erectile Dysfunction?

Erectile disfunction should be treated with the appropriate medications like the PDE5 inhbitors—not testosterone—testosterone may make it so you flirt half a time more a day but that is not likely wor...

16 Feb 20248min

Episode 241: 241. Does Testosterone Therapy Prevent or Cause Fractures?

Episode 241: 241. Does Testosterone Therapy Prevent or Cause Fractures?

even at very small some would argue barely even treating doses of testosterone patients had an increase rate of fractures with a NNH of 100—when you add this to the 1 risk of aki and 2 percent risk of...

15 Feb 20245min

Episode 240: 240. Does Testosterone Prevent the Progression of Pre-diabetes to Diabetes?

Episode 240: 240. Does Testosterone Prevent the Progression of Pre-diabetes to Diabetes?

Risk of progression from prediabetes to diabetes did not differ significantly between testosterone and placebo groups- and they looked for a change at 6,12,24,36,48 months of follow upNot to sound lik...

14 Feb 20245min

Episode 239: 239. TRAVERSE Study...Is Testosterone Therapy Safe for the Heart?

Episode 239: 239. TRAVERSE Study...Is Testosterone Therapy Safe for the Heart?

Take awayThe drug companies will say look how safe testosterone therapy is there was no difference in death from cardiovascular causes or myocardial infarction or stroke in those individuals randomize...

13 Feb 202410min

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