Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Episoder(385)

Episode 190: Medical Update 190 (GERD, Diabetes, Carpal Tunnel, VTE)

Episode 190: Medical Update 190 (GERD, Diabetes, Carpal Tunnel, VTE)

Extended Follow-up of Local Steroid Injection for Carpal Tunnel Syndrome: A Randomized Clinical Trial | Neuropathy | JAMA Network Open | JAMA Network Looked at just over 100 patients with carpal tunne...

8 Feb 202218min

Episode 189: Medical Update 189 (Vit d., Pregnancy test, Heart Failure, Acetazolamide)

Episode 189: Medical Update 189 (Vit d., Pregnancy test, Heart Failure, Acetazolamide)

Writing Group for the CODA Collaborative. Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis. JAMA Surg 2022 Jan 12; [e-pub]. Now, investig...

30 Jan 202224min

Episode 188: Medical Update 188 (KDIGO, pseudoanemia, Coronary calcium score, cardiogenic shock, UTI)

Episode 188: Medical Update 188 (KDIGO, pseudoanemia, Coronary calcium score, cardiogenic shock, UTI)

https://pubmed.ncbi.nlm.nih.gov/33734980/if you lay flat with a blood draw you may have psuedoanemiahttps://jamanetwork.com/journals/jama/fullarticle/2782300Men and UTI-- 7 dayshttps://jamanetwork.com...

14 Jan 202221min

Episode 187: 187. FAFP CME -- Top Articles of 2021

Episode 187: 187. FAFP CME -- Top Articles of 2021

Yes this is a CME lecture but yes you get it for the expensive price of Free Fifty Free....

10 Des 202146min

Episode 186: 186. ACE vs ARB, Blood Clots, and Mifepristone

Episode 186: 186. ACE vs ARB, Blood Clots, and Mifepristone

Contraception 2021 Sep 20;[EPub Ahead of Print], D Grossman, S Raifman, N Morris, A Arena, L Bachrach, J Beaman, MA Biggs, C Hannum, S Ho, EB Schwarz, M GoldSTUDY DESIGNThis is an interim analysis of ...

30 Nov 20215min

Episode 185: 185. USPSTF, Lupus, Diabetes Risk Factor, C. Diff

Episode 185: 185. USPSTF, Lupus, Diabetes Risk Factor, C. Diff

Davidson KW et al. Screening for prediabetes and type 2 diabetes: US Preventive Services Task Force recommendation statement. JAMA 2021 Aug 24; 326:736. (https://doi.org/10.1001/jama.2021.12531)  The ...

3 Sep 202121min

Episode 184: 184. Question and Answer From the Last Two Podcast

Episode 184: 184. Question and Answer From the Last Two Podcast

I've found that I can often increase compliance with statins by having pt take them 3x/week or QOD.  I try this often especially in my secondary prevention group. I understand "any statin is better th...

25 Jul 202124min

Episode 183: 183. PART 2 DYSH Out Information on DYSlipidemia, an Evidence Based Approach

Episode 183: 183. PART 2 DYSH Out Information on DYSlipidemia, an Evidence Based Approach

DYSh out information on DYSlipidemia: An Evidence-based Update on Cholesterol ManagementPlease contact me for more information:    Andrew Buelt, D.O.  andrewbuelt@gmail.com Questioning Medic...

15 Jul 202116min

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