Episode 320: 319. President Biden has COVID, Should the First Lady Take Paxlovid?

Episode 320: 319. President Biden has COVID, Should the First Lady Take Paxlovid?

https://www.nejm.org/doi/full/10.1056/NEJMoa2309002
In this placebo-controlled trial, postexposure prophylaxis with nirmatrelvir–ritonavir for 5 or 10 days did not significantly reduce the risk of symptomatic SARS-CoV-2 infection.


https://www.nejm.org/doi/full/10.1056/NEJMoa2309003

https://www.nejm.org/doi/full/10.1056/NEJMoa2118542


Pfizer has some serious problems! #pfizer

Episoder(385)

Episode 270: 269. What is the Harm in Aspirin?

Episode 270: 269. What is the Harm in Aspirin?

The trial was terminated after  1015 patients with atrial cardiopathy had been randomized to receive either apixaban or aspirin for a mean follow-up of 1.8 years, recurrent stroke rates were identical...

15 Apr 20244min

Episode 268: 268. New Guidelines For Total Hip and Knee Joint Replacement

Episode 268: 268. New Guidelines For Total Hip and Knee Joint Replacement

TJA should not be delayed for trials of physical therapy, anti-inflammatory drug use, bracing, intra-articular steroid injections, or hyaluronic acid injections. For patients with obesity, proceed to...

12 Apr 20247min

Episode 269: 267. Beta Blockers DON'T Help Post-MI

Episode 269: 267. Beta Blockers DON'T Help Post-MI

randomized trial comparingbeta-blocker therapy (metoprolol or bisoprolol) with no beta-blocker in 5020 patients who had a normal left-ventricular ejection fraction (LVEF) after AMI median follow-up of...

11 Apr 20246min

Episode 267: 266. How Many Years Of Smoking Cessation Do You Need?

Episode 267: 266. How Many Years Of Smoking Cessation Do You Need?

During a mean 11 years of follow-up, current smokers' risks for cardiovascular-, cancer-, and respiratory-related deaths were 2, 3, and 13 times higher, respectively, than never smokers' risks. Former...

10 Apr 20245min

Episode 266: 265. Semaglutide and Cardiovascular Events in Non-Diabetics (secondary prevention) SELECT TRIAL

Episode 266: 265. Semaglutide and Cardiovascular Events in Non-Diabetics (secondary prevention) SELECT TRIAL

The primary cardiovascular end point was a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke in a time-to-first-event analysis.Improvement innonfatal st...

9 Apr 20248min

Episode 265: 264. Does a Lidocaine Patch Work for Neck Pain?

Episode 265: 264. Does a Lidocaine Patch Work for Neck Pain?

Bottom line(ZTLido 1.8%) is a brand name lidocaine patch currently approced for postherpetic neuralgia and will stay that why for now as it did not beat placebo for the treatment of patients with chro...

5 Apr 20245min

Episode 264: 263. Rates of Atrial Fibrillation 12 months After Onset of Hospitalized Transient AF

Episode 264: 263. Rates of Atrial Fibrillation 12 months After Onset of Hospitalized Transient AF

patients who have new-onset transient AF detected during a hospitalization for noncardiac surgery or medical illness and are discharged in sinus rhythm, approximately 1 in 3 have AF detected in the ye...

4 Apr 20247min

Episode 263: 262. Does Omalizumab Help For Peanut Allergy?

Episode 263: 262. Does Omalizumab Help For Peanut Allergy?

Bottom line Omalizumab does seem to improve allergic reactions to peanuts but comes at a steep price tag. Likely only allergist will prescribe this drug but it is worth know about If you know or take ...

3 Apr 20248min

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