Are GLP-1 Drugs "the Greatest Medical Breakthrough of the 21st Century"?

Are GLP-1 Drugs "the Greatest Medical Breakthrough of the 21st Century"?

In the past few years, we've learned that GLP-1 drugs don’t just help with diabetes or increase people’s feelings of fullness to help them lose weight. They have broad effects on substance abuse and behavior. They even seem to help with otherwise incurable illnesses, like Alzheimer's and schizophrenia. This month, a team of scientists studying 2 million patients in the Veterans Affairs medical system found that GLP-1s were associated with “a reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimer’s disease and dementia), coagulation disorders (clotting), cardiometabolic disorders (like strokes and heart attacks), infectious illnesses and several respiratory conditions.” Today’s guest is a coauthor on the paper, Ziyad Al-Aly. He is a physician-scientist at Washington University in St. Louis. We talk about his new paper, the steps he took to make sure his findings were trustworthy, why GLP-1 drugs might work so well, what they’re teaching us about the brain and body, how they’re scrambling our sense of where volition begins and where free will ends, and what scientists should do next with the revelation that these drugs have effects that go far beyond obesity and diabetes. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Ziyad Al-Aly Producer: Devon Baroldi Links: Al-Aly et al. on the effectiveness and risks of GLP-1 drugs [link] Learn more about your ad choices. Visit podcastchoices.com/adchoices

Episoder(348)

Crypto Crash Part I: The Case Against Crypto

Crypto Crash Part I: The Case Against Crypto

Today, we have the first in a two-part series on lessons from the crypto crash. Crypto, also known as Web3, also known as blockchain-based technologies, remains the weirdest space I’ve ever reported o...

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Why It Seems Like So Many Countries Are Falling Apart

Why It Seems Like So Many Countries Are Falling Apart

The world is kind of a mess right now. There is a big, bloody, awful war between Russia and Ukraine, which has hugely disrupted global trade, especially in commodities like oil, wheat, and natural gas...

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The world is on fire. In southern Europe, wildfires are streaking from Portugal to Greece. In the U.K., airport runways melted as temperatures exceeded 103 degrees for the first time on record. In the...

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Three Ways the Elon Musk–Twitter Showdown Could End

Three Ways the Elon Musk–Twitter Showdown Could End

Well, that escalated quickly. Let's review, shall we? In January, Elon Musk started buying a bunch of Twitter stock. In February, he kept buying. In March, he owned about 5 percent of the company. In ...

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Burning Questions About the Future of Media: Netflix vs. Disney, TikTok vs. Everyone, and the Metaverse

Will Netflix be the king of streaming in five years? What's the biggest threat to dethrone it: Apple, Disney, or HBO? Are movie theaters back for real? How has the pandemic changed the film industry? ...

12 Jul 20221h 12min

Musk Meltdown: Elon’s Breakup With Twitter Is Going to Be Very Messy

Musk Meltdown: Elon’s Breakup With Twitter Is Going to Be Very Messy

Derek has so many thoughts on Elon Musk's bizarre attempted breakup with Twitter—and what comes next—that he has to enumerate them. In this episode, he goes through five reasons Elon is trying to wrig...

10 Jul 202217min

The Biggest Economic Question of the Moment: Is This Peak Inflation?

The Biggest Economic Question of the Moment: Is This Peak Inflation?

The question everybody's asking on cable news right now is whether we're in a recession. I think there's an even more important question to ask: Are we at peak inflation? If inflation U-turns, it mean...

8 Jul 202232min

Why Are the Police So Bad at Solving Murders?

Why Are the Police So Bad at Solving Murders?

Today’s episode is about the story of the moment—gun violence. There’s been a surge of violent shootings, mass shootings, and gun-related murders in the last few years. Today, Derek investigates a mys...

6 Jul 202247min

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