Long COVID the Answers4 Jan 2025

Episode 27 - Long COVID Research & Potential Treatments Part 1 – with Professor David Putrino PhD

Professor David Putrino is a physiotherapist with a PhD in Neuroscience. He is currently the Director of Rehabilitation Innovation for the Mount Sinai Health System, and a Professor in the Department of Rehabilitation and Human Performance at the Icahn School of Medicine at Mount Sinai. Professor Putrino recently opened the Mount Sinai Cohen Center for Recovery from Complex Chronic Illness in New York also known as (CoRE) and serves as CoRE’s Family Director and is also a member of PolyBio’s Long COVID Research Consortium.

Today we talk about the pathophysiology of Long COVID in the context of describing research into targeted treatments for the disease.

REFERENCES

1 Proal AD, VanElzakkerMB, Aleman S, Bach K, Boribong BP, Buggert M, Cherry S, Chertow DS, Davies HE, Dupont CL, Deeks SG. SARS-CoV-2 reservoir in post-acute sequelae of COVID-19(PASC). Nature Immunology. 2023 Oct;24(10):1616-27.

2 Klein J, Wood J,Jaycox JR, Dhodapkar RM, Lu P, Gehlhausen JR, Tabachnikova A, Greene K, Tabacof L, Malik AA, Silva Monteiro V. Distinguishing features of Long COVID identified through immune profiling. Nature. 2023 Nov 2;623(7985):139-48.

3 Long COVID low-dose Rapamycin clinical trial

4 Lumbrokinase LongCOVID & ME/CFS clinical trial

5 Silva J, Takahashi T, Wood J, Lu P, Tabachnikova A, Gehlhausen JR, Greene K,

Bhattacharjee B, Monteiro VS, Lucas C, Dhodapkar RM. Sex differences in

symptomatology and immune profiles of Long COVID. medRxiv. 2024 Mar 2:2024-02.

6 VanElzakker MB, Bues HF, Brusaferri L, Kim M, Saadi D, Ratai EM, Dougherty DD, Loggia ML. Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [11C] PBR28 PET correlates with vascular disease measures. Brain, Behavior, and Immunity.

7 Fernández-CastañedaA, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O’Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell. 2022 Jul 7;185(14):2452-68.

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Episoder(28)

Podcast Special - Addressing the Costs & Care for Long COVID An OECD Report

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W.H.O. Long COVID Exclusive

Dr Funmi Okunola MD conducts three interviews with 4 representatives of the World Health Organization -Dr Maria Van Kerkhove PhD -Director of the Department of Epidemic & Pandemic Threat Management;Dr...

26 Mar 44min

Episode 28 - Long COVID Research & Potential Treatments Part 2– with Professor David Putrino

11 Jan 202517min

Episode 26 - A Potential Treatment & Biomarker for Long COVID with Professor Nancy Klimas

Professor Nancy Klimas is interviewed about the mechanisms behind how a nebulised medication caused a remarkable recovery from symptoms of ME/CFS and Long COVID in a small group of individuals and her...

28 Des 202443min

Episode 25 - Mast-Cell Activation Syndrome & Long COVID with Dr David Lyons Kaufman MD

Dr David Lyons Kaufman is interviewed about Mast Cell Activation Syndrome. Dr Kaufman is a working member of the U.S. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Clinical Coalition an...

21 Des 202436min

Episode 24 - The Patient-Led Research Collaborative Part 2 with Gina Assaf & Letícia Soares

Gina Assaf & Letícia Soares are interviewed about the work they do as part of the Patient-Led Research Collaborative. In this episode we do a deep dive into their latest publication.REFERENCES1 Soare...

14 Des 202438min

Episode 23 - Are Monoclonal Antibodies a Possible Treatment for Long COVID? With Professor Nancy Klimas

Dr Funmi Okunola MD interviews Professor Nancy Klimas MD about her research into the use of Monoclonal Antibodies as a possible treatment for Long COVID. We have an exciting and exclusive breaking ne...

7 Des 202420min