Chronic Leukemias

Ninja Nerds! In this episode of the Ninja Nerd Podcast, Zach and Rob discuss testicular cancer, one of the most common solid tumors in young adult men. We begin with a classic clinical vignette of a young male presenting with a painless testicular mass. From there, we explore the epidemiology and key risk factors for testicular germ cell tumors, including cryptorchidism, family history, and Klinefelter syndrome (in rare cases of nonseminomatous tumors like mediastinal choriocarcinoma). We th...

9 Okt 20min

Ninja Nerds! In this episode of the Ninja Nerd Podcast, Zach and Rob dive into the essential clinical and pathophysiologic features of urinary tract malignancies, beginning with renal cell carcinoma (RCC) and followed by urothelial carcinoma of the bladder. We start with a patient case of renal cell carcinoma, exploring the epidemiology and risk factors such as smoking, obesity, hypertension, and inherited syndromes like von Hippel-Lindau disease. The discussion focuses on the pathophysiolog...

25 Sep 29min

Ninja Nerds! In this episode of the Ninja Nerd Podcast, Zach and Rob break down the essential clinical and pathophysiologic features of Prostate Cancer, one of the most common malignancies affecting men worldwide. We begin with the epidemiology and risk factors, highlighting age, race, family history, and androgen exposure. From there, we explore the pathogenesis of prostate cancer, focusing on the role of androgen receptor signaling. The discussion covers clinical manifestations, including u...

11 Sep 34min

Ninja Nerds! In this episode of the Ninja Nerd Podcast, Zach and Rob discuss Colorectal Cancer. This comprehensive discussion focuses on the clinical presentation, pathogenesis, and management of one of the most common malignancies encountered in clinical practice. We start by breaking down the epidemiology and risk factors, covering both sporadic and inherited forms—highlighting Lynch syndrome and familial adenomatous polyposis (FAP). From there, we analyze the adenoma-carcinoma sequenc...

4 Sep 37min

Ninja Nerds! In this episode of the Ninja Nerd Podcast, Zach and Rob explore the complex world of Brain Tumors. We explore the key types of brain tumors—both primary and metastatic—and examine their clinical implications through high-yield pathophysiology, neuroanatomy, and diagnostic principles. The discussion begins with an overview of tumor classification, distinguishing between supratentorial and infratentorial masses, and covers the most common tumors seen in adults versus children. Zach...

8 Mai 35min

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Lung Cancer, a leading cause of cancer-related mortality worldwide. We explore the pathophysiology, risk factors, and key differences between non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) to help you master this complex topic. Our discussion covers the clinical presentation of lung cancer, including subtle early symptoms like cough, hemoptysis, and chest pain, as well as advan...

4 Apr 46min

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Myelodysplastic Syndrome (MDS), a group of hematologic disorders characterized by ineffective hematopoiesis and a risk of progression to acute myeloid leukemia (AML). We also discuss the pathophysiology of MDS, highlighting the clonal stem cell mutations that lead to dysplastic bone marrow changes and peripheral blood cytopenias. Our discussion explores the clinical presentation of MDS, from common ...

28 Mar 26min

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Breast Cancer's pathogenesis, risk factors, and the latest advancements in screening, diagnosis, and treatment. We break down the molecular subtypes of breast cancer, including hormone receptor-positive, HER2-positive, and triple-negative disease, and discuss their clinical implications and targeted therapies. Our discussion covers essential diagnostic tools, such as mammography, breast ultrasound, M...

21 Mar 44min