Nature Podcast5 Mar 2025

Earliest crafted bone tools date back 1.5 million years

00:46 Ancient humans made bone tools 1.5 million years ago

A 1.5-million-year-old cache of animal-bone tools reveals that ancient humans systematically crafted with this material much earlier than previously thought. Researchers uncovered 27 bone artefacts in Tanzania honed into sharp tools almost 40 cm long. This discovery pushes back the dedicated manufacture of bone tools by around a million years and could have helped these early humans develop new kinds of technology. “This raises a lot of interesting questions,” says study author Ignacio de la Torre.

Research Article: de la Torre et al.

09:11 Research Highlights

Cane toads’ remarkable homing abilities, and evidence that the block of rock that makes up southern Tibet originated in what is now Australia.

Research Highlight: Take me home, country toads

Research Highlight: Lhasa′s rocks reveal an Australian birthplace

11:45 A trove of antibacterial molecules hidden in human proteins

To help protect against infection, cells in the body will selectively cut proteins to produce molecules known as antimicrobial peptides, according to new research. A team has found that many potential peptides appear to be locked up within proteins — to get them out, cells shift the activity of a waste-disposal system called the proteasome, known for its role in protein degradation and recycling. In tests, one of these peptides showed efficacy at protecting mice from infection, indicating that these molecules could one day have therapeutic potential.

Research Article: Goldberg et al.

News and Views: Protein waste turned into antibiotics as a defence strategy of human cells

21:08 Briefing Chat

An update on two missions heading to the Moon to look for water, and why fears that a crucial ocean-current system will collapse in the face of climate change may be incorrect.

Nature: Meet the ice-hunting robots headed for the Moon right now

Nature: Iconic ocean-current system is safe from climate collapse ― for now

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Episoder(906)

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