#274 – Karl Deisseroth: Depression, Schizophrenia, and Psychiatry

Jason Calacanis is an angel investor, entrepreneur, and co-host of All-In Podcast and This Week in Startups. Please support this podcast by checking out our sponsors: – Brave: https://brave.com/lex – Linode: https://linode.com/lex to get $100 free credit – Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off – Rev: https://rev.ai/lex to get 7-day free trial EPISODE LINKS: Jason’s Twitter: https://twitter.com/Jason Jason’s Website: https://calacanis.com/ Jason’s YouTube: https://www.youtube.com/user/ThisWeekIn Jason’s Link Tree: https://linktr.ee/calacanis All-In Podcast: https://linktr.ee/allinpodcast This Week in Startups Podcast: https://thisweekinstartups.com/about/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/LexFridmanPage – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (06:52) – WallStreetBets and Robinhood (17:58) – How does the WallStreetBets saga end? (21:09) – Capitalism (26:30) – Ideas vs Execution (27:38) – Learning to learn (33:06) – Risk-aversion (39:07) – Robinhood (47:33) – Parler and AWS (49:59) – Social networks (56:33) – Leadership (1:01:21) – Work-life balance (1:09:44) – Great leaders lead by example (1:17:30) – Advice for startup founders (1:21:57) – Clubhouse (1:22:42) – When will we fully re-open the economy (1:33:20) – Augmented reality (1:36:48) – When should a startup raise money? (1:43:44) – David Goggins (1:45:40) – Disagreement with Chamath Palihapitiya (1:58:52) – Story about Elon Musk’s darkest moments (2:07:08) – Friendship

15 Feb 20212h 16min

Brendan Eich is the creator of JavaScript and co-founder of Mozilla and Brave. Please support this podcast by checking out our sponsors: – The Jordan Harbinger Show: https://jordanharbinger.com/lex/ – Sun Basket: https://sunbasket.com/lex and use code LEX to get $35 off – BetterHelp: https://betterhelp.com/lex to get 10% off – Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Brendan’s Twitter: https://twitter.com/BrendanEich Brendan’s Website: https://brendaneich.com Brave browser: https://brave.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/LexFridmanPage – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (06:54) – History of early programming languages (11:47) – Physics needs more experiments and less theory (16:24) – JavaScript origin story (41:17) – JavaScript was created in 10 days (50:57) – Marc Andreessen (54:14) – Internet Explorer (57:58) – Evolution of JavaScript (1:03:44) – JavaScript standardization (1:09:33) – TypeScript (1:12:05) – JavaScript ecosystem (1:15:15) – HTML5 (1:18:47) – Making JavaScript fast (1:27:57) – JavaScript is the most popular language in the world (1:38:23) – Advice for programmers (1:44:20) – Browser wars (1:50:50) – Firefox (2:12:33) – Brave (2:25:33) – Basic Attention Token (2:50:36) – California (2:59:48) – Mortality (3:00:54) – Legacy

12 Feb 20213h 4min

Richard Craib is the founder of Numerai, a crowd-sourced, AI-run stock trading system. Please support this podcast by checking out our sponsors: – Audible: https://audible.com/lex to get $9.95 a month for 6 months – Tryolabs: https://tryolabs.com/lex – Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium – Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil EPISODE LINKS: Richard’s Twitter: https://twitter.com/richardcraib Numerai’s Twitter: https://twitter.com/numerai Numerai’s Website: https://numer.ai PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/LexFridmanPage – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (08:12) – WallStreetBets and GameStop saga (22:25) – Evil shorting and chill shorting (24:31) – Hedge funds (30:04) – Vlad (37:00) – Numerai (1:04:16) – Futre of AI in stock trading (1:09:55) – Numerai data (1:13:37) – Is stock trading gambling or investing? (1:17:32) – What is money? (1:20:49) – Cryptocurrency (1:24:06) – Dogecoin (1:28:36) – Advice for startups (1:44:27) – Book recommendations (1:46:29) – Advice for young people (1:50:30) – Meaning of life

7 Feb 20211h 55min

Zev Weinstein is a young man who thinks deeply about the world. Please support this podcast by checking out our sponsors: – ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free – Grammarly: https://grammarly.com/lex to get 20% off premium – SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera – Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off EPISODE LINKS: Zev’s YouTube: https://www.youtube.com/c/GenerationZW Zev’s Twitter: https://twitter.com/zev__weinstein Zev’s Instagram: https://www.instagram.com/zev_weinstein/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/LexFridmanPage – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (06:52) – Philosophy becomes dangerous in difficult times (12:15) – The power of radical ideas (17:06) – Changing your mind (21:19) – Fear (22:58) – Labels (28:02) – Thomas Aquinas (32:32) – Nietzsche (37:02) – Nature of truth (39:22) – Jordan Peterson (44:54) – Mediums of communication (53:24) – Free will (57:48) – Simulation (1:02:05) – Transcending the limits of human life (1:05:09) – Elon Musk (1:09:30) – Aliens (1:13:01) – Is math invented or discovered? (1:15:36) – Theory of everything (1:17:30) – Eric Weinstein as a dad (1:33:17) – Music (1:40:32) – Advice for young people (1:42:31) – Mortality (1:46:19) – Meaning of life

5 Feb 20211h 49min

Natalya Bailey is a rocket propulsion engineer from MIT and now CTO of Accion Systems. Please support this podcast by checking out our sponsors: – Munk Pack: https://munkpack.com and use code LEX to get 20% off – Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off – Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium – Sun Basket: https://sunbasket.com/lex and use code LEX to get $35 off EPISODE LINKS: Natalya’s Twitter: https://twitter.com/natalya926 Accion Systems: https://accion-systems.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/LexFridmanPage – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (06:51) – Intelligent life in the universe (10:52) – Life in our solar system (12:57) – Humans on Mars (16:31) – Robots vs human in space exploration (17:25) – AI in space (21:30) – How rocket engines work (26:47) – How ion engines work (31:10) – How colloid engines work (40:07) – Material science (42:57) – Nuclear powered rocket engines (47:56) – Electric propulsion out in space (51:23) – Satellites (56:17) – Photo of Earth from the Moon (57:55) – Humans on Mars (1:00:17) – Propulsion without fuel (1:08:12) – How to build a rocket company (1:15:10) – SpaceX and commercial spaceflight (1:19:42) – Advice to startup founders (1:26:18) – Book recommendations (1:34:36) – Meaning of life

1 Feb 20211h 39min

Tim Dillon is a comedian and podcaster. Please support this podcast by checking out our sponsors: – NetSuite: http://netsuite.com/lex to get free product tour – Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil – Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off – BetterHelp: https://betterhelp.com/lex to get 10% off – Rev: https://rev.ai/lex to get 7-day free trial EPISODE LINKS: Tim’s Twitter: https://twitter.com/TimJDillon Tim’s Instagram: https://www.instagram.com/timjdillon Tim’s YouTube: https://www.youtube.com/channel/UC4woSp8ITBoYDmjkukhEhxg Tim’s Website: https://www.timdilloncomedy.com Tim’s Merch: https://www.bonfire.com/store/the-tim-dillon-show/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/LexFridmanPage – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (08:00) – Tim Dillon’s tombstone (09:55) – The horrible people are the most fun (14:06) – Charles Bukowski (19:46) – Robots (22:56) – YouTube algorithm (29:04) – Parler and Amazon (33:32) – Social media (36:09) – Alex Jones (54:42) – OJ Simpson (59:22) – Politics (1:05:52) – Donald Trump (1:13:09) – Humor (1:20:44) – QAnon (1:27:13) – Conspiracy theories (1:32:50) – Bill Gates (1:35:20) – Elon Musk (1:37:35) – Jeffrey Epstein (1:40:14) – Ghislaine Maxwell (1:47:55) – Greatest comedians of all time (1:57:53) – Love (2:01:24) – Fear (2:04:38) – Mom (2:08:10) – Mortality (2:10:13) – Advice for young people (2:16:47) – Moving to Austin (2:24:40) – Meaning of life

29 Jan 20212h 29min

Please support this podcast by checking out our sponsors: – Brooklinen: https://brooklinen.com and use code LEX to get $25 off + free shipping – Indeed: https://indeed.com/fridman to get $75 credit – ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free – Theragun: https://theragun.com/lex to get 30 day trial PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/LexFridmanPage – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (06:37) – Will AGI suffer from depression? (11:14) – Love is an escape from the muck of life (17:14) – What questions would you ask an alien? (25:58) – How to pivot careers to computer science (33:06) – What will robots look like in the future? (35:54) – Disagreement with Einstein about happiness (41:50) – How I pick podcast guests (51:26) – How to stay optimistic about the future (59:09) – Major topics I changed my mind on (1:06:39) – Benefits of keto diet (1:16:02) – Darkest time in my life

27 Jan 20211h 19min

Max Tegmark is a physicist and AI researcher at MIT. Please support this podcast by checking out our sponsors: – The Jordan Harbinger Show: https://www.jordanharbinger.com/lex/ – Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off – BetterHelp: https://betterhelp.com/lex to get 10% off – ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free EPISODE LINKS: News Project Explainer Video: https://www.youtube.com/watch?v=PRLF17Pb6vo News Project Website: https://www.improvethenews.org/ Max’s Twitter: https://twitter.com/tegmark Max’s Website: https://space.mit.edu/home/tegmark/ Future of Life Institute: https://futureoflife.org/ Lex Fridman Podcast #1: https://www.youtube.com/watch?v=Gi8LUnhP5yU PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/LexFridmanPage – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (08:15) – AI and physics (21:32) – Can AI discover new laws of physics? (30:22) – AI safety (47:59) – Extinction of human species (58:57) – How to fix fake news and misinformation (1:20:30) – Autonomous weapons (1:35:54) – The man who prevented nuclear war (1:46:02) – Elon Musk and AI (1:59:39) – AI alignment (2:05:42) – Consciousness (2:14:45) – Richard Feynman (2:18:56) – Machine learning and computational physics (2:29:53) – AI and creativity (2:41:08) – Aliens (2:56:51) – Mortality

18 Jan 20213h 8min