In Vivo27 Jan 2025

Parasites as Medicine? Dr. Andrea Choe on Immunomodulation & Autoimmune Disease | Ep. 16

Can worms revolutionize medicine? Dr. Andrea Choe, CEO of Holoclara, is pioneering worm-derived molecules for human health. In this episode of In Vivo, we explore:- The surprising relationship between gut worms and the immune system- How worm-derived molecules could treat autoimmune diseases- Fascinating historical cases of humans coexisting with gut worms- The journey of Holoclara’s breakthrough drug into Phase 1 trialsDr. Choe explains the science of immunomodulation, the role of gut parasites in human health, and why modern medicine might be missing an evolutionary advantage.Listen in to uncover how gut worms could lead to the next wave of innovative treatments!Introduction and Congratulations - 00:02:12Background on Gut Worm Symbiosis - 00:02:51Journey into Worm Research - 00:03:09Historical Context of Gut Worms - 00:05:16Hypothesis on Immuno Modulation - 00:05:55Evolution of Gut Worms and Humans - 00:08:07Benefits of Gut Worms in Health - 00:09:26Public Perception and Black Market Treatments - 00:10:15Evidence for Immuno Modulation - 00:11:39Bio Prospecting with Worms vs. Rainforests - 00:15:54Molecule Selection for Human Trials - 00:16:53Challenges in Worm Research - 00:18:22Characteristics of Worm Researchers - 00:20:46Protein vs. Small Molecule Research - 00:22:40Philosophy of Staying Close to Nature - 00:26:13Reception of Worm-Derived Medicine in Biotech - 00:29:22Balancing Roles as PhD, MD, and Entrepreneur - 00:31:39Overview of Hola Clara - 00:33:06Leadership and Management Inspiration - 00:33:33Phase One Trials and Eosinophilic Esophagitis - 00:36:22Future Applications Beyond Current Trials - 00:39:01Navigating Research Biases - 00:40:44Regulatory Challenges with Worms - 00:43:04Timeline for Market Availability - 00:44:11Advice for Aspiring Scientist-Entrepreneurs - 00:45:19Personal Journey with Worm-Derived Medicine - 00:46:59Worm Atlas and Personalized Medicine - 00:48:01Ethical Considerations - 00:51:16Future Vision for Hola Clara - 00:52:19Closing Remarks - 00:53:11Holoclara website - https://www.holoclara.com/In Vivo on X - https://x.com/InVivoPodOnXIn Vivo on Spotify - https://open.spotify.com/show/5GBvPPvSx52O6ILuam4LoX?si=6c903566ae7b4761&nd=1&dlsi=254f9f5e78194002In Vivo on Apple Podcast - https://podcasts.apple.com/us/podcast/in-vivo/id1775578563In Vivo on Amazon Podcasts - https://music.amazon.ca/podcasts/1ac4dbec-df46-4d1f-b0a1-742e9656ef44/in-vivo

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Episoder(49)

LSD, Schizophrenia & The Madness Pill: Psychiatry’s Wildest Experiment | Dr. Justin Garson | Ep. 49

Philosopher and historian of science Dr. Justin Garson joins me to unpack The Madness Pill: One Doctor’s Quest to Understand Schizophrenia, the mid-century hunt for a pill that could temporarily induc...

13 Okt 1h 30min

Autonomous Labs and the Coming Biotech Singularity | In Vivo w/ Dr. Jason Kelly | Ep. 48

Dr. Jason Kelly, co-founder and CEO of Ginkgo Bioworks, joins me to unpack autonomous labs, what they are, why biology’s bench tooling barely moved in 20 years, and why the right analogy isn’t a subwa...

29 Sep 1h 2min

Editing Embryos: The Biotech Frontier That Changes Everything | Cathy Tie and Prof. Jiang | Ep. 47

Cathy Tie (founder, Origin Genomics) and Prof. Jiang Xueqin (Predictive History) join me for a wide-open conversation on germline gene editing, the science, the ethics, and the geopolitics.Cathy walks...

15 Sep 1h 30min

Einstein’s 1913 Warning, Variable Light Speed, and Why He May Be WRONG | Jason Verbelli | Ep. 46

Jason Verbelli, founder of Galilean Variance and CEO/Lead Engineer at SEG Magnetics, argues that Einstein left a written test for his own theory: if the speed of light depends even a little on the mot...

1 Sep 1h 51min

Psychopaths Do Not Exist: The Zombie Idea Explained | Dr. Rasmus Rosenberg Larsen | Ep. 45

In this episode of In Vivo, I sit down with Dr. Rasmus Rosenberg Larsen, Assistant Professor of Forensic Epistemology at the University of Toronto and author of Psychopathy Unmasked: The Rise and Fall...

18 Aug 2h

Rockets Get Us to Mars. Biology Decides If We Can Stay | Ryan T. Scott of NASA AMES | Ep. 44

In this episode, NASA space biologist Ryan T. Scott explains why biology, not rocket science, is the real limiting factor in humanity’s goal of becoming a multi-planetary species. We discuss how NASA’...

4 Aug 1h 9min

Do Single Cells Possess Agency? Learning and Memory Without a Brain | Dr. Arjun Raj | In Vivo Ep. 43

Can a single cell learn?In this episode of In Vivo, I sit down with systems and single-cell biologist Dr. Arjun Raj (University of Pennsylvania) to explore one of the most provocative ideas in modern ...

22 Jul 1h 29min

Dr. Michael Shermer: Now is The Time to Think Like a Scientist | In Vivo | Ep. 42

In this wide-ranging conversation, Dr. Michael Shermer, founder of Skeptic Magazine and the Skeptics Society, opens up about his personal journey from born-again Christian to one of the world’s most r...

7 Jul 1h 27min