198 | Nick Lane on Powering Biology

The origin of life here on Earth was an important and fascinating event, but it was also a long time ago and hasn't left many pieces of direct evidence concerning what actually happened. One set of clues we have comes from processes in current living organisms, especially those processes that seem extremely common. The Krebs cycle, the sequence of reactions that functions as a pathway for energy distribution in aerobic organisms, is such an example. I talk with biochemist about the importance of the Krebs cycle to contemporary biology, as well as its possible significance in understanding the origin of life.

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Nick Lane received his PhD from the Royal Free Hospital Medical School. He is currently a professor of Evolutionary Biochemistry at University College London. He was a founding member of the UCL Consortium for Mitochondrial Research, and is Co-Director of the UCL Centre for Life's Origin and Evolution. He was awarded the 2009 UCL Provost's Venture Research Prize, the 2011 BMC Research Award for Genetics, Genomics, Bioinformatics and Evolution, the 2015 Biochemical Society Award, and the 2016 Royal Society Michael Faraday Prize and Lecture. His new book is Transformer: The Deep Chemistry of Life and Death.


Episoder(419)

348 | Jessica Riskin on Jean-Baptiste Lamarck and Life as Creative Agency

348 | Jessica Riskin on Jean-Baptiste Lamarck and Life as Creative Agency

"Lamarkism" is a term often attached to a seemingly discredited idea in evolutionary biology: that one organism could acquire characteristics (e.g., becoming stronger through exercise) that would then...

23 Mar 1h 15min

347 | Andrew Guthrie Ferguson on How Your Data Will Be Used Against You

347 | Andrew Guthrie Ferguson on How Your Data Will Be Used Against You

In the 18th century, philosopher Jeremy Bentham suggested the Panopticon as a model of a prison where inmates could be constantly observed by just a single prison guard. Although his original idea was...

16 Mar 1h 8min

346 | Erica Cartmill on How Human and Animal Minds Think and Play

346 | Erica Cartmill on How Human and Animal Minds Think and Play

Intelligence is a many splendored thing, especially when it comes to comparisons between species. Chimpanzees are better than humans at some numerical tasks, but less good at understanding what number...

9 Mar 1h 28min

AMA | March 2026

AMA | March 2026

Welcome to the March 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patre...

2 Mar 3h 53min

345 | Adam Elga on Being Rational in a Very Large Universe

345 | Adam Elga on Being Rational in a Very Large Universe

Behaving rationally involves facing up to conditions of uncertainty; we never navigate the world with perfect confidence. Sometimes we are uncertain about the way the world is, but we can also be unce...

23 Feb 1h 34min

344 | Adam Gurri on Liberal Democracy and How to Fight For It

344 | Adam Gurri on Liberal Democracy and How to Fight For It

It's possible to look at the course of history over the past few centuries and discern a movement toward increasing democracy, freedom, and individual rights -- "liberalism," in the political-philosop...

16 Feb 1h 21min

343 | Tom Griffiths on The Laws of Thought

343 | Tom Griffiths on The Laws of Thought

For all that human beings spend a lot of their time thinking, it's far from obvious what that process actually entails. Part of it amounts to classical logical reasoning. But an even bigger part invol...

9 Feb 1h 19min

AMA | Feb 2026

AMA | Feb 2026

Welcome to the February 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Pa...

2 Feb 3h 10min

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