Episode 278: 277. What Do You Do With Subclinical Hypothyroidism?
In older adults, mildly elevated TSH levels normalized in about 50% of cases during 1 to 2 years of observation.https://academic.oup.com/jcem/article/109/3/e1167/7325863?login=true
25 Apr 20244min
Episode 277: 276. REDUCE-MI Trial- Should we still Give BBlockers Post-MI?
A study that was done before the widespread use of troponin only measurements for ACS (and certainly before high sensitively trop EVER EXISTED), a trial that took place before the first statin was ev...
24 Apr 20246min
Episode 276: 275. Do SSRI Increase The Rate Of Bleeding With Anticoagulants?
This translates into an absolute excess risk of ≈9 events per 1000 person-years or 1 per 110 person years. Sad differently if you treat 110 people for 1 year with a doac and an SSRI you will have one ...
23 Apr 20245min
Episode 275: 274. Do Your Genes ACTUALLY Make You Obese?
During follow-up participants walked on average 8300 steps and those individuals in the lowest genetic risk score developed obesity defined as a BMI greater than 30 approximately 13% of the time while...
22 Apr 20248min
Episode 274: 273. Does Telerehabilitation Work For Chronic Knee Pain?
And in the end it did not really matter because at 3 months individuals only reported a 0.16 difference in pain and a 1.6 difference in function which both were well within the noninferiority boundary...
19 Apr 20248min
Episode 273: 272. Does Bariatric Surgery Work in Diabetics For Cardiovascular Events
At 1 year 50% of those individuals who had bariatric surgery were able to achieve diabetic remission but after 12 years the very same individuals that received bariatric surgery had just a 13% success...
18 Apr 20248min
Episode 272: 271. Cologaurd Has a New Test? How Good is it?
The company that developed Cologuard also developed this “next generation” multitarget stool DNA test, and has applied for U.S. FDA approval. The new test appears to have similar sensitivity and highe...
17 Apr 20245min
Episode 271: 270. Aprocitentan, How Well Does it Work for Resistant Hypertension?
730 Patients were randomized to receive daily oral aprocitentan or placebo, plus a fixed-dose combination of amlodipine, valsartan, and hydrochlorothiazide.After 4 weeks, mean change in office systoli...
16 Apr 20246min
