S2 Episode 1: What's Next? Clinical Trials in Myelofibrosis

Drs Tania Jain and Ruben Mesa discuss the clinical trials and the future of myelofibrosis research.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002053. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Myeloproliferative Neoplasms (MPNs) Have a Significant Impact on Patients' Overall Health and Productivity: The MPN Landmark Survey https://pubmed.ncbi.nlm.nih.gov/26922064/

A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/22375971/

The Myelofibrosis Symptom Assessment Form (MFSAF): An Evidence-Based Brief Inventory to Measure Quality of Life and Symptomatic Response to Treatment in Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/19250674/

Practical Measures of Clinical Benefit With Ruxolitinib Therapy: An Exploratory Analysis of COMFORT-I https://pubmed.ncbi.nlm.nih.gov/28606598/

The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF): International Prospective Validation and Reliability Trial in 402 Patients https://pubmed.ncbi.nlm.nih.gov/21536863/

Randomized, Single-Blind, Multicenter Phase II Study of Two Doses of Imetelstat in Relapsed or Refractory Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/34138638/

Phase III MANIFEST-2: Pelabresib + Ruxolitinib vs Placebo + Ruxolitinib in JAK Inhibitor Treatment-Naive Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/35950489/

Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis (TRANSFORM-2) https://clinicaltrials.gov/study/NCT04468984

Allogeneic Stem Cell Transplant for Patients With Myeloproliferative Neoplasms in Blast Phase: Improving Outcomes in the Recent Era https://pubmed.ncbi.nlm.nih.gov/33821472/

Efficacy and Safety of Ruxolitinib After and Versus Interferon Use in the RESPONSE Studies https://pubmed.ncbi.nlm.nih.gov/29396713/