ENCORE: Running rats and healing hearts

ENCORE: This episode was first published in Sept. 2023.

In 1998, a young Norwegian exercise physiologist found that a technique he had used to help Olympic athletes could help heart patients too. But his idea made doctors sweat. One famous cardiologist told him that if he used his technique in human heart attack patients, he "would kill them."

Today's show looks at what happened when our researcher, Ulrik Wisløff, defied the experts — and built a career learning how high intensity interval training can help everyone from heart patients and ageing Baby Boomers, and possibly even Alzheimer's patients — but not in the way you might think!

Today's guests are Ulrik Wisløff, Dorthe Stensvold and Atefe Tari.

Here's a link to a rat on a treadmill photo. And here's a link to a transcript.

Here's a list of some of the research mentioned in the podcast:

• Wisløff U, et al. Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1301-10.
• Wisløff U,et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007 Jun 19;115(24):3086-94. doi: 10.1161/CIRCULATIONAHA.106.675041. Epub 2007 Jun 4.
• Rognmo, Ø et al.. Cardiovascular Risk of High- Versus Moderate-Intensity Aerobic Exercise in Coronary Heart Disease Patients Circulation. 2012;126:1436-1440. doi: 10.1161/CIRCULATIONAHA.112.123117
• Stensvold D, Viken H, Steinshamn S L, Dalen H, Støylen A, Loennechen J P et al. Effect of exercise training for five years on all cause mortality in older adults—the Generation 100 study: randomised controlled trial BMJ 2020; 371 :m3485
• Tari AR, Nauman J, Zisko N, Skjellegrind HK, Bosnes I, Bergh S, Stensvold D, Selbæk G, Wisløff U. Temporal changes in cardiorespiratory fitness and risk of dementia incidence and mortality: a population-based prospective cohort study. Lancet Public Health. 2019 Nov;4(11):e565-e574.
• Tari AR, Berg HH, Videm V, Bråthen G, White LR, Røsbjørgen RN, Scheffler K, Dalen H, Holte E, Haberg AK, Selbaek G, Lydersen S, Duezel E, Bergh S, Logan-Halvorsrud KR, Sando SB, Wisløff U. Safety and efficacy of plasma transfusion from exercise-trained donors in patients with early Alzheimer's disease: protocol for the ExPlas study. BMJ Open. 2022 Sep 6;12(9):e056964.

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