#30 - Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?

#30 - Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?

In this episode, Thomas Seyfried, a cancer researcher and professor of biology at Boston College, discusses a controversial view of cancer as a mitochondrial metabolic disease. Many topics related to the causes, treatments, and prevention of cancer are covered in this in-depth conversation.

We discuss:

  • How Tom got interested in cancer research [9:00];
  • Calorie-restricted ketogenic diets, fasting, and epileptic seizures [18:30];
  • Otto Warburg and the Warburg effect [30:45];
  • Germline mutations, somatic mutations, and no mutations [42:00];
  • Mitochondrial substrate level phosphorylation: Warburg's missing link [51:30];
  • What is the structural defect in the mitochondria in cancer? [1:02:00];
  • Peter's near-death experience with the insulin suppression test while in ketosis [1:06:30];
  • Insulin potentiation therapy and glutamine inhibition [1:13:15];
  • The macrophage fusion-hybrid theory of metastasis [1:39:30];
  • How are cancer cells growth dysregulated without a mutation? [1:47:00];
  • What is the dream clinical trial to test the hypothesis that we can reduce the death rates of cancer by 50%? [2:03:15];
  • How can the hypothesis be tested rigorously that structural abnormalities in the mitochondria impair respiration and lead to compensatory fermentation? [2:26:30];
  • Case studies of GBM survivors [2:32:45]; and
  • More.

Learn more at www.PeterAttiaMD.com

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Episoder(434)

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter explains how to eva...

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#360 ‒ How to change your habits: why they form and how to build or break them | Charles Duhigg, M.B.A

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Charles Duhigg is a Pulitzer Prize-winning journalist and best-sel...

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#359 ‒ How metabolic and immune system dysfunction drive the aging process, the role of NAD, promising interventions, aging clocks, and more | Eric Verdin, M.D.

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Eric Verdin is a physician-scientist and the CEO of the Buck Insti...

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#358 ‒ Peter's takeaways on navigating HRT, rejuvenating the face, understanding the biology of aging, optimizing fertility, and learning to live well from the dying | Quarterly Podcast Summary #6

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this quarterly podcast summary (QPS) episode, Peter summarizes ...

28 Jul 202512min

#357 ‒ A new era of longevity science: models of aging, human trials of rapamycin, biological clocks, promising compounds, and lifestyle interventions | Brian Kennedy, Ph.D.

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Brian Kennedy is a renowned biologist, leader in aging research, a...

21 Jul 20251h 56min

#356 - AMA #73: Preserving brain health, optimizing exercise programming, improving body composition, and more

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View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter addresses frequentl...

14 Jul 202517min

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