#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer's disease treatment and prevention – is AD actually a vascular and metabolic disease?
The Peter Attia Drive28 Jan 2019

#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer's disease treatment and prevention – is AD actually a vascular and metabolic disease?

In this episode, Francisco Gonzalez-Lima, a Professor of Neuroscience and Pharmacology & Toxicology, explains the vascular hypothesis of Alzheimer's disease which says the central problem is a progressive neuronal energy crisis of impaired blood flow to the brain and impaired mitochondrial respiration. He walks us through the ways we can intervene in this process and also shares details of the exciting future of Alzheimer's treatment and prevention.

We discuss:

  • Background and interest in the brain [5:15];
  • The unique nature of the human brain [9:15];
  • Why we've made so little progress in Alzheimer's research [23:00];
  • The amyloid beta hypothesis [28:30];
  • Hypometabolism in the brain leading to cognitive decline [39:30];
  • Early signs of AD, and deciphering between age-related decline versus something pathologic [47:45];
  • The vascular hypothesis of Alzheimer's disease [54:00];
  • The relationship between mitochondria, cytochrome c oxidase, and Alzheimer's disease [1:08:00];
  • Chronic inhibition of cytochrome c oxidase leads to chronic neurodegenerative disease [1:22:45];
  • Major risk factors for AD, head trauma, and other forms of dementia [1:33:45];
  • Methylene blue for treating and preventing neurodegeneration [1:38:15];
  • Current standard of care for AD, and the reasons for a lack of advancement [2:01:45];
  • Near infrared light as a targeted treatment for cognitive decline [2:05:30];
  • The ketogenic diet as a treatment and preventative measure [2:13:15];
  • Exciting future research coming from Francisco [2:23:00];
  • Methylene blue for traumatic brain injuries [2:25:15]; and
  • More.

Learn more at www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.

Episoder(433)

#376 - AMA #78: Longevity interventions, exercise, diagnostic screening, and managing high apoB, hypertension, metabolic health, and more

#376 - AMA #78: Longevity interventions, exercise, diagnostic screening, and managing high apoB, hypertension, metabolic health, and more

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter tackles a wide-rang...

15 Des 202522min

#375 - Ketogenic diet, ketosis & hyperbaric oxygen: metabolic therapies for weight loss, cognition, Alzheimer's & more | Dom D'Agostino, Ph.D.

#375 - Ketogenic diet, ketosis & hyperbaric oxygen: metabolic therapies for weight loss, cognition, Alzheimer's & more | Dom D'Agostino, Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Dom D'Agostino is a neuroscientist and professor at the forefront ...

8 Des 20252h 8min

#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Carole Hooven is a human evolutionary biologist whose research cen...

1 Des 20252h 5min

The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green (#288 rebroadcast)

The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green (#288 rebroadcast)

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Walter Green is a remarkable philanthropist, mentor, author of Thi...

24 Nov 20251h 31min

#373 – Thyroid function and hypothyroidism: why current diagnosis and treatment fall short for many, and how new approaches are transforming care | Antonio Bianco, M.D., Ph.D.

#373 – Thyroid function and hypothyroidism: why current diagnosis and treatment fall short for many, and how new approaches are transforming care | Antonio Bianco, M.D., Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Antonio Bianco is a world-renowned physician-scientist and expert ...

17 Nov 20252h 20min

#372 - AMA #77: Dietary fiber and health outcomes: real benefits, overhyped claims, and practical applications

#372 - AMA #77: Dietary fiber and health outcomes: real benefits, overhyped claims, and practical applications

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter breaks down the sci...

10 Nov 202524min

#371 – Women's sexual health: desire, arousal, and orgasms, navigating perimenopause, and enhancing satisfaction | Sally Greenwald, M.D., M.P.H.

#371 – Women's sexual health: desire, arousal, and orgasms, navigating perimenopause, and enhancing satisfaction | Sally Greenwald, M.D., M.P.H.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Sally Greenwald is an OB-GYN who specializes in women's sexual hea...

3 Nov 20251h 52min

Longevity 101: a foundational guide to Peter's frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more (re-broadcast)

Longevity 101: a foundational guide to Peter's frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more (re-broadcast)

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode, Peter provides a comprehensive introducti...

27 Okt 20251h 25min

Populært innen Helse

fastlegen
lydartikler-fra-aftenposten
rss-gukild-johaug
hvordan-har-du-det-mann
psykodrama
leger-om-livet
rss-garne-damer
relasjonspodden-med-dora-thorhallsdottir-kjersti-idem
foreldreradet
morten-ramm-lar-kakla-ga-til-du-sovner
rss-lopedrommen
hormonelle-frida
hjernesterk
klimaks
g-punktet
hverdagspsyken
sinnsyn
bak-fasaden-en-reise-i-livet-med-sykepleier-ine
treningsprat
kjed-deg-i-sovn-verdens-kjedeligste-podcast