Building a Company that Builds Companies

Building a Company that Builds Companies

Noubar Afeyan is the co-founder of Moderna and the founder of Flagship Pioneering. His problem: How do you turn the chaotic hero's journey of entrepreneurship into a repeatable, systematic process?


Noubar created Flagship Pioneering to solve the problems he saw with entrepreneurship. Flagship's mission: To create new companies in a systematic, repeatable way. On today's show, Noubar explains how that system led to the creation of Moderna, a company that developed a COVID vaccine and saved millions of lives.


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Episoder(212)

The Printing Press: The Invention Built on Debt and Sin… from Business History

The Printing Press: The Invention Built on Debt and Sin… from Business History

Before 1450, books were written out by hand. It was slow and expensive. But Johannes Gutenberg borrowed a ton of money to create a printing press that could crank out Bibles and pamphlets and document...

24 Sep 46min

Should We Pause AI?

Should We Pause AI?

Everybody’s worried about the risks of AI. So we called up one of the most insightful writers we know on the subject: Zvi Mowshowitz. Zvi writes about AI and AI risks at his substack, Don’t Worry Abou...

17 Sep 44min

Bonus: Planning for Your Financial Future

Bonus: Planning for Your Financial Future

On this bonus episode of What’s Your Problem, Jacob talks to Christine Chase, a Vice President, Financial Consultant at Fidelity Investments. Christine’s problem is this: How do you help clients build...

15 Sep 10min

Can a Robot Kill Fish Humanely?

Can a Robot Kill Fish Humanely?

The fish we eat usually die slowly, suffocating after they’re pulled out of the water. Saif Khawaja is the co-founder and CEO of a company called Shinkei. Saif's problem is this: Can he build a machin...

10 Sep 38min

Using Satellites to Prevent Famines

Using Satellites to Prevent Famines

Catherine Nakalembe is an assistant professor at the University of Maryland and the head of the Africa program at NASA Harvest, which uses satellite images to track agriculture around the world. Cathe...

3 Sep 36min

The Quantum Shift in Biomedical Discovery from Smart Talks with IBM

The Quantum Shift in Biomedical Discovery from Smart Talks with IBM

When Dr. Lara Jehi began treating epilepsy patients in the 2000s, critical surgical decisions were driven more by clinician intuition and expertise than data. Today, she is a leader of IBM and Clevela...

20 Aug 44min

Can We Slow Down Aging?

Can We Slow Down Aging?

Nir Barzilai is a physician and a researcher at the Albert Einstein College of Medicine in New York, where he runs the Institute for Geroscience. Nir’s problem is this: How can we use lifestyle change...

13 Aug 36min

Why Doctors Use Evidence but Managers (Mostly) Don’t

Why Doctors Use Evidence but Managers (Mostly) Don’t

Helen Pearson is the author of the book “Beyond Belief: How Evidence Shows What Really Works.” Helen's problem is this: How do you get people to make important decisions based on high-quality evidence...

6 Aug 41min

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