Innovative Approaches to Bone and Joint Infections Part 1
Joint Approach9 Sep 2025

Innovative Approaches to Bone and Joint Infections Part 1

Host Jessica Seidelman, MD has an in-depth discussion with Kerry LaPlante, Pharm.D., FCCP, FIDSA, FIDP, and Julie Ann Justo, Pharm.D. in the opening episode of this 3-part series. They discuss why PJI infections are so difficult to treat, and advances in antimicrobial agents in the pipeline. This episode is sponsored by BONESUPPORT™, makers of CERAMENT® G with Gentamicin. CERAMENT G is an FDA-designated breakthrough device offering proven bone remodeling with reliable elution of broad-spectrum Gentamicin. CERAMENT G has a 96% success rate in eradication of infection in a single-stage for patients with fracture related infections and chronic osteomyelitis. To learn more and review CERAMENT G cases, visit their website at BONESUPPORT.com

Listen to Breakpoints: The SIDP Podcast

References:

“Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection” PMID 34042388

“NDM-9 resistance to taniborbactam” PMID 36796395

“Wide dissemination of Gram-negative bacteria producing the taniborbactam-resistant NDM-9 variant: a One Health concern” PMID 37394537

IDSA 2024 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections

“Dalbavancin for the Treatment of Osteomyelitis in Adult Patients: A Randomized Clinical Trial of Efficacy and Safety” PMID 30648126

“Corynebacterium striatum Prosthetic Joint Infection Successfully Treated with Long-Term Dalbavancin” PMID 36985124

“Emergence of Dalbavancin, Vancomycin, and Daptomycin Nonsusceptible Staphylococcus aureus in a Patient Treated with Dalbavancin: Case Report and Isolate Characterization” PMID 35510938

“Local antibiotic delivery via intra-articular catheter infusion for the treatment of periprosthetic joint infection: a systematic review” PMID 38691147

“A High-Affinity Native Human Antibody Disrupts Biofilm from Staphylococcus aureus Bacteria and Potentiates Antibiotic Efficacy in a Mouse Implant Infection Model” PMID 26833157

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Episoder(77)

French Advances in Bacterial Phage Therapy for PJI: Part 1

French Advances in Bacterial Phage Therapy for PJI: Part 1

Hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD chat with Professor Tristan Ferry, MD, PhD, Tiphaine Roussel-Gaillard, PharmD, PhD, and Thomas Briot, PharmD, PhD in part 1 of this 2-part conve...

6 Okt 29min

Candidal PJI: Uncommon and Unforgettable, Part 2

Candidal PJI: Uncommon and Unforgettable, Part 2

In the conclusion of this series on candidal PJI's, hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD discuss this challenging issue with Martin McNally, MD FRCSEd FRCS(Orth) and Aurélien Dinh, ...

22 Sep 31min

Candidal PJI's: Uncommon and Unforgettable, Part 1

Candidal PJI's: Uncommon and Unforgettable, Part 1

Hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD chat with MartinMcNally, MD FRCSEd FRCS(Orth) and Aurélien Dinh, MD, PhD in part 1 of this 2-part conversation on candidal prosthetic joint infe...

8 Sep 26min

Does the "5-second" Rule Apply to Dropped Medical Objects in the OR?

Does the "5-second" Rule Apply to Dropped Medical Objects in the OR?

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD, and guests Sam Rosas, MD, PhD, David Weber, MD, MPH, and Bobby Warren, MPS, as they review the artcile entitled: "The "five-second" rule f...

18 Aug 29min

Bugged and Baffled: A Case with Meredith Schade, Kelan Queenan, and Kevin Perry Part 2

Bugged and Baffled: A Case with Meredith Schade, Kelan Queenan, and Kevin Perry Part 2

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4 Aug 28min

Bugged and Baffled: A Case with Meredith Schade, Kelan Queenan, and Kevin Perry- Part 1

Bugged and Baffled: A Case with Meredith Schade, Kelan Queenan, and Kevin Perry- Part 1

Join hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD in this Case Study Series entitled Bugged and Baffled. In part 1 of this 2-part series, they discuss a challenging case with Meredith Schad...

21 Jul 28min

Lysins: A Next Generation Treatment Option for PJI? Part 2

Lysins: A Next Generation Treatment Option for PJI? Part 2

In the final episode of this 2-part series, Jessica Seidelman, MD and Johannes Plate, MD, PhD conclude the conversation with Gina Suh, MD, Ken Urish, MD, PhD, and Ray Schuch, PhD on the topic of innov...

7 Jul 26min

Lysins: A Next Generation Treatment Option for PJI? Part 1

Lysins: A Next Generation Treatment Option for PJI? Part 1

Hosts Jessica Seidelman, MD and Johannes Plate, MD, PhD chat with Gina Suh, MD, Ken Urish, MD, PhD, and Ray Schuch, PhD in part 1 of this 2-part conversation on the topic of innovation in treatment of...

23 Jun 27min

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