Dementia Researcher Blogs11 Sep 2025

Dr Clíona Farrell - Genetically determined Alzheimer’s; recap from ADAD-DSAD

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website.

Genetically determined Alzheimer’s disease, though rare, offers key insights into dementia research. In this blog, Dr Clíona Farrell recaps highlights from the ADAD-DSAD conference in Barcelona. Covering autosomal dominant Alzheimer’s disease and Down syndrome-related Alzheimer’s, she explores genetics, APOE’s role in symptom onset, clinical trial progress for anti-amyloid therapies in people with Down syndrome, and the vital importance of lived experience and PPIE in shaping research.

Find the original text, and narration here on our website.

https://www.dementiaresearcher.nihr.ac.uk/blog-genetically-determined-alzheimers-adad-dsad-recap/

Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer’s disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson’s disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_
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This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support.

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