If GLP-1 Drugs Are Good for Everything, Should We All Be on Them?

If GLP-1 Drugs Are Good for Everything, Should We All Be on Them?

To read more of Derek's reporting on GLP-1 drugs, you can subscribe to his Substack here. GLP-1 drugs like Ozempic and Zepbound don't just help with Type 2 diabetes and weight loss. They seem to curb alcohol, cocaine, and tobacco use among addicts. In some studies, they prevent strokes, heart attacks, chronic kidney disease, sleep apnea, and Parkinson's disease. They’re associated with a lower risk of several cancers, including pancreatic cancer and multiple myeloma. Arthritic patients on the drugs experienced relief from knee pain that was “on par with opioid drugs.” A small study found that they reduce migraine headaches by 50 percent. And emerging research suggests they might even slow the rate of memory loss among people diagnosed with Alzheimer’s. Is all of this real? And if it’s real, how is one drug doing so many different things? And if it is doing all those things, why shouldn’t we be developing versions of the drug for just about everyone? Today we have two guests: David D’Alessio, chief of endocrinology and metabolism at the Duke University School of Medicine; and Randy Seeley, a professor of surgery, internal medicine, and nutritional sciences at the University of Michigan. We talk about how these drugs work—why they seem to do everything—and how our understanding of them could make them better, more effective, more broadly useful. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guests: David D’Alessio and Randy Seeley Producer: Devon Baroldi Disclosure: Dr. Seeley has received research support from several pharmaceutical companies, including Eli Lilly, Diasome, and Amgen. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Episoder(348)

A Mysterious Health Wave Is Breaking Out Across the U.S.

A Mysterious Health Wave Is Breaking Out Across the U.S.

Why do Americans die younger than citizens of other rich countries? The most important reason is that life in America is inexcusably dangerous. The U.S. has more fatalities from gun violence, drug ove...

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The Productivity Paradox: Why Less Is More With Oliver Burkeman

The Productivity Paradox: Why Less Is More With Oliver Burkeman

So, here’s a scenario: It’s Monday. And you open up whatever calendar or planner or to-do list you use to organize the essential activities of the upcoming week. There’s a large project due Thursday. ...

20 Des 20241h 1min

Why American Health Care Is a "Broken System"

Why American Health Care Is a "Broken System"

Last week, UnitedHealthcare CEO Brian Thompson was shot to death outside a hotel in Manhattan by a young man motivated by rage at the insurance industry. His rage is clearly felt widely. In the afterm...

13 Des 20241h 21min

Is Crypto Entering a New Golden Age—or Just a New Era of Failed Promises?

Is Crypto Entering a New Golden Age—or Just a New Era of Failed Promises?

The crypto industry seems poised for a new golden age. But what exactly does that mean? Who would benefit? And, oh by the way, what does this technology do other than serve as a set of assets to bet t...

6 Des 202450min

Megapod: Why Is There So Much BS in Psychology?

Megapod: Why Is There So Much BS in Psychology?

In the last decade, several major findings in social psychology have turned out to be hogwash—or, worse, even fraud. This has become widely known as psychology's "replication crisis." Perhaps you have...

27 Nov 20241h 48min

Vaccine Conspiracies, Fluoride Myths, and America’s Broken Public-Health Discourse

Vaccine Conspiracies, Fluoride Myths, and America’s Broken Public-Health Discourse

Emily Oster, professor of economics at Brown University, joins the show to talk about Robert F. Kennedy Jr., his theories about fluoride and vaccines, and how the media and science community should tr...

22 Nov 202439min

The Self-Driving Revolution Is Real—and It Could Be Spectacular

The Self-Driving Revolution Is Real—and It Could Be Spectacular

What would a world of self-driven cars look like? How would it change shopping, transportation, and life, more broadly? A decade ago, many people were asking these questions, as it looked like a boom...

15 Nov 20241h 8min

How Trump Won: Young Men’s Red Wave, the Blue-City Flop, and the Incumbency Graveyard

How Trump Won: Young Men’s Red Wave, the Blue-City Flop, and the Incumbency Graveyard

Derek shares his big-picture theory for Trump's victory. Then, Republican pollster Kristen Soltis Anderson explains how Trump shifted practically the entire electorate to the right. Links: Derek's ar...

8 Nov 202452min

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