Sarcopenia, Frailty and Risk Prediction in Geriatric Patients

Sarcopenia, Frailty and Risk Prediction in Geriatric Patients

As people age, loss of muscle mass is inevitable, resulting in sarcopenia. Muscle loss contributes to overall weakness, which causes frailty. Frailty, in turn, is the generalized susceptibility to disease and injury, all of which causes loss of autonomy. Because of the potential for progressive decline in physical function in very elderly patients, accurate tools are needed to predict mortality risk to individualize treatments intended to improve longevity such as chemotherapy, management of chronic diseases, and surgery. In this podcast, sarcopenia, frailty, and risk prediction are discussed in the context of major trials studying them being conducted in Europe.

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Episoder(505)

Heart Transplant for Advanced Heart Failure

Heart Transplant for Advanced Heart Failure

Heart transplant for patients with advanced heart failure can lead to improved survival and quality of life. Author JoAnne Lindenfeld, MD, of Vanderbilt University joins JAMA Associate Editor David Si...

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Narcolepsy: A Review

Narcolepsy: A Review

Narcolepsy is a chronic neurologic disorder that causes severe daytime sleepiness and impaired quality of life. Author Tom Scammell, MD, of Harvard Medical School joins JAMA Deputy Editor Karen Lasser...

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Influenza, RSV, and COVID-19 Vaccines: Effectiveness, Safety, and Trust in 2026

Influenza, RSV, and COVID-19 Vaccines: Effectiveness, Safety, and Trust in 2026

Respiratory virus vaccine effectiveness and safety for influenza, RSV, and COVID-19 are reviewed, including new evidence, risks, and recommendations. JAMA Deputy Editor Preeti Malani, MD, MSJ, speaks ...

30 Sep 14min

Vaccines for Cancer Treatment

Vaccines for Cancer Treatment

Cancer vaccines stimulate immune cells to recognize proteins or mutations found on or within cancer cells, facilitating destruction of cancer cells. Several vaccines are approved and others are in dev...

21 Sep 20min

Idiopathic Normal Pressure Hydrocephalus: Diagnosis and Treatment

Idiopathic Normal Pressure Hydrocephalus: Diagnosis and Treatment

Idiopathic normal pressure hydrocephalus (iNPH) affects approximately 1% to 4% of adults aged 65 years and older and is associated with gait impairment, cognitive decline, and urinary dysfunction. Aut...

14 Sep 19min

Rheumatoid Arthritis

Rheumatoid Arthritis

Rheumatoid arthritis can affect any synovial joint and cause irreversible damage, but early diagnosis and treatment with DMARDs can reduce inflammation and lower the risk of joint destruction. JAMA As...

10 Sep 23min

An Overview of Postural Orthostatic Tachycardia Syndrome (POTS)

An Overview of Postural Orthostatic Tachycardia Syndrome (POTS)

POTS is a chronic autonomic disorder characterized by excessive orthostatic tachycardia and multisystem symptoms that affects an estimated 0.1% to 1% of the US population. Author Satish Raj, MD, MSCI,...

24 Aug 28min

Medication Treatments for Alcohol Use Disorder

Medication Treatments for Alcohol Use Disorder

Naltrexone, acamprosate, disulfiram, and topiramate are effective but underused medications for treatment of alcohol use disorder. Author Stephen Holt, MD, MS, of Yale School of Medicine joins JAMA De...

19 Aug 20min

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